Epipregnanolone
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Epipregnanolone
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CAS No:
128-21-2
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Formula:
C21H34O2
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Chemical Name:
Epipregnanolone
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Synonyms:
Pregnan-20-one,3-hydroxy-,(3β,5β)-;5β-Pregnan-20-one,3β-hydroxy-;(3β,5β)-3-Hydroxypregnan-20-one;Epipregnanolone;3β-Hydroxy-5β-tetrahydroprogesterone;5β-Pregnan-3β-ol-20-one;3β-Hydroxy-5β-pregnan-20-one;5β-Pregnane-3β-ol-20-one;5β-Pregnane-3β-hydroxy-20-one;3β-Hydroxy-5β-pregnane-20-one;Pregnanolone I;3β,5β-Pregnanolone;3-Deoxo-3β-hydroxy-5β-dihydroprogesterone;NSC 21450
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CAS No:
Description
ChEBI: The 3beta-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.
Solid
3beta-hydroxy-5beta-pregnan-20-one is the 3beta-stereoisomer of 3-hydroxy-5beta-pregnan-20-one. It has a role as a human metabolite and a mouse metabolite. It is a 3-hydroxy-5beta-pregnan-20-one and a 3beta-hydroxy steroid.|A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
Characteristics
37.3
4.59520
Solid
1.053±0.06 g/cm3(Predicted)
136 °C
431.2±18.0 °C(Predicted)
183.9ºC
1.524
Drug Information
Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site. (See all compounds classified as Anesthetics.)
3 alpha Hydroxy 5 alpha pregnan 20 one
Epipregnanolone Use and Manufacturing
Epipregnanolone is an epimer of the hyponotic-anaesthetic agent Pregnanolone (P711300). Epipregnanolone displaysanesthetic, hypnotic, and sedative properties. Epipregnanolone has been shown to reduce alcohol self-administration in rats.
Lipids -> Sterol Lipids [ST] -> Steroids [ST02] -> C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]
Computed Properties
Molecular Weight:318.5
XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:318.255880323
Monoisotopic Mass:318.255880323
Topological Polar Surface Area:37.3
Heavy Atom Count:23
Complexity:500
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes