Noscapine
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Noscapine
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CAS No:
128-62-1
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Formula:
C22H23NO7
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Chemical Name:
Noscapine
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Synonyms:
1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(3S)-;Narcotine;1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,[S-(R*,S*)]-;1,3-Dioxolo[4,5-g]isoquinoline,1(3H)-isobenzofuranone deriv.;(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone;Narcosine;Nectadon;Noscapine;α-Narcotine;Longatin;Coscopin;Coscotabs;O-Methylnarcotoline;Narcotin;Opianine;Narkotin;Noscapin;Opianin;Nicolane;Narcompren;Noscapalin;Narcotussin;Opian;(-)-Narcotine;(-)-α-Narcotine;Longactin;l-α-Narcotine;L-α-Noscapine;Tusscapine;Terbenol;Vadebex;NSC 5366;Methoxyhydrastine;Nipaxon;Capval;Lyobex;567-86-2;1368-39-4;8055-18-3;8057-19-0
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CAS No:
Description
Crystalline SolidChEBI: A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from p ants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects.
Characteristics
75.7
2.83
Solid
1.395 g/cm3
176 °C
532.6°C (rough estimate)
295.7±30.1 °C
1.5614 (estimate)
Practically insoluble in water, soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in strong acids; on dilution of the solution with water, the base may be precipitated.
-20°C Freezer, Under Inert Atmosphere
cyt-ham:lng 100 mg/L ATSUDG (4),41,80
-200 º (c=1 in chloroform)
ODORLESS
VERY BITTER TASTE
NEUTRAL TO LITMUS
Safety Information
III
6.1(b)
1544
3
22
24/25
RD2625000
Xn
STABLE IN LIGHT & AIR
P301 + P312 + P330
H302
Drug Function and Efficacy
Antitussive
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