ALPHA-MSH
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ALPHA-MSH
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CAS No:
581-05-5
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Formula:
C77H109N21O19S
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Chemical Name:
ALPHA-MSH
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Synonyms:
a-MSH;C02758;ALPHA-MSH;-MSH;ALPHA-MSH,AMIDE;ALPHA-MSN,HUMAN;alpha-Intermedin;ALPHA-MELANOTROPIN;α-Melanotropin【pig】;AC-SYSMEHFRWGKPV-NH2
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CAS No:
Description
α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.
Drug Information
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects. (See all compounds classified as Hormones.)
(Des-Acetyl)-alpha-MSH
Computed Properties
Molecular Weight:1664.9
XLogP3:-4.3
Hydrogen Bond Donor Count:23
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:51
Exact Mass:1663.79293151
Monoisotopic Mass:1663.79293151
Topological Polar Surface Area:668
Heavy Atom Count:118
Complexity:3370
Defined Atom Stereocenter Count:12
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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