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Lincomycin

Lincomycin structure

CAS No:
154-21-2
Formula:
C18H34N2O6S
Chemical Name:
Lincomycin
Synonyms:
D-erythro-α-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-;D-erythro-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,trans-α-;D-erythro-α-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,(2S-trans)-;Lincomycin;Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside;U 10,149A;Lincomycin A;Lincolcina;Cillimycin;Jiemycin;U 10149;Lincolnensin;Medoglycine;12768-69-3;16977-76-7
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

White Crystalline SolidChEBI: A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.

Lincomycin Basic Attributes

Molecular Weight：

406.54

Exact Mass：

406.54

EC Number：

205-824-6

HScode：

2941904000

Characteristics

PSA：

148

XLogP3：

0.20

Appearance：

White crystalline solid

Density：

1.1704 (rough estimate)

Melting Point：

148-150°C

Boiling Point：

646.8±55.0 °C(Predicted)

Flash Point：

345ºC

Refractive Index：

1.6510 (estimate)

Water Solubility：

In water, 927 mg/L at 25 deg C (est)

Storage Conditions：

Lincomycin hydrochloride injection should be stored at 20-25 deg C; freezing should be avoided.

Vapor Pressure：

1.34X10-17 mm Hg at 25 deg C (est)

Toxicity：

LD50 oral in rat: 1gm/kg

Safety Information

Marks：

Stability/Shelf Life：

Stable in light and air. /Lincomycin HCl, USP/

Lincomycin Use and Manufacturing

Methods of Manufacturing

Streptomyces (Streptomyces lincolnensis) mutant strain produced by fermentation.

Uses

Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N-methylproline, coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

Drug Function and Efficacy

Antibiotics, with an antibacterial spectrum similar to erythromycin, mainly have high antibacterial activity against Gram-positive bacteria, and its mechanism of action is to inhibit bacterial protein synthesis

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lincomycin Lidocaine Gel
Ingredients	This product is a compound preparation, containing 5 mg of lincomycin and 4 mg of lidocaine per gram.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	(1) 10 g: 0.05 g (C18H34N2O6S) and 0.04 g (C14H22N2O.HCl) (2) 20 g: 0.1 g (C18H34N2O6S) and 0.08 g (C14H22N2O.HCl)
Manufacturer	Guangdong Zhanjiang Jimin Pharmaceutical Co., Ltd.

Lincomycin Lidocaine Gel
Ingredients	This product is a compound preparation, containing 5 mg of lincomycin and 4 mg of lidocaine per gram.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	10g: 50mg (C18H34N2O6S) and 40mg (C14H22N2O·HCl)
Manufacturer	Bai Cao Tang Pharmaceutical Co., Ltd.

Lincomycin Lidocaine Gel
Ingredients	This product is a compound preparation, containing 5 mg of lincomycin and 4 mg of lidocaine per gram.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	10g:0.05g(C18H34N2O6S) and 0.04g(C14H22N2O.HCl)
Manufacturer	Tiansheng Pharmaceutical Group Co., Ltd.

See More Related Drugs

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Hangzhou Hyper Chemicals Limited Contact Supplier

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CAS No.: 154-21-2

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CAS No.: 154-21-2

Content: 98%

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Lincomycin

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Guide of Lincomycin

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
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Lincomycin

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