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Antazoline phosphate

Antazoline phosphate structure

CAS No:
154-68-7
Formula:
C17H19N3.H3O4P
Chemical Name:
Antazoline phosphate
Synonyms:
1H-Imidazole-2-methanamine,4,5-dihydro-N-phenyl-N-(phenylmethyl)-,phosphate (1:1);2-Imidazoline,2-[(N-benzylanilino)methyl]-,phosphate (1:1);Antazoline phosphate;Antistine phosphate;2-[(N-Benzylanilino)methyl]-2-imidazoline dihydrogen phosphate
Categories:
Analytical Chemistry > Standard

Description

Antazoline Phosphate is the phosphate salt of antazoline, an ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, gastrointestinal and bronchial smooth muscles. These histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Antazoline is used to provide symptomatic relieve of allergic symptoms.|An antagonist of histamine H1 receptors.

Antazoline phosphate Basic Attributes

Molecular Weight：

363.35

Exact Mass：

363.134796

EC Number：

205-831-4

UNII：

VPR5FPH326

NSC Number：

755865

DSSTox ID：

DTXSID00165507

NCI Thesaurus Code：

C47399

Characteristics

PSA：

115.20000

XLogP3：

1.53070

Appearance：

COA

Density：

0.975 g/mL at 25 °C(lit.)

Melting Point：

194-198 °C

Boiling Point：

235-236 °C(lit.)

Flash Point：

>230 °F

Refractive Index：

n20/D 1.517(lit.)

Vapor Pressure：

3.31E-09mmHg at 25°C

Collision Cross Section：

162.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P280-P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302 + H312 + H332-H315-H319-H335

Drug Information

MeSH：

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

MeSH Entry Terms：

Analergine

Antazoline phosphate Use and Manufacturing

Uses

Antazoline Phosphate acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:363.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:363.13479319
Monoisotopic Mass:363.13479319
Topological Polar Surface Area:105
Heavy Atom Count:25
Complexity:364
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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