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Benztropine mesylate

Benztropine mesylate structure

CAS No:
132-17-2
Formula:
C21H25NO.CH4O3S
Chemical Name:
Benztropine mesylate
Synonyms:
8-Azabicyclo[3.2.1]octane,3-(diphenylmethoxy)-8-methyl-,(3-endo)-,methanesulfonate (1:1);1αH,5αH-Tropane,3α-(diphenylmethoxy)-,methanesulfonate;8-Azabicyclo[3.2.1]octane,3-(diphenylmethoxy)-8-methyl-,endo-,methanesulfonate;8-Azabicyclo[3.2.1]octane,3-(diphenylmethoxy)-8-methyl-,(3-endo)-,methanesulfonate;MK 02;Benzatropine methanesulfonate;Benzotropine methanesulfonate;Benztropine mesylate;Benztropine methanesulfonate;Cobrentin methanesulfonate;Cogentin methanesulfonate;3-Diphenylmethoxytropane mesylate;3-Diphenylmethoxytropane methanesulfonate;Tropine benzohydryl ether methanesulfonate;Benzotropine mesylate;Cogentin;Cogentinol;NSC 169913;NSC 42199
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.Target: mAChRBenzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease. It may also be used to treat extrapyramidal reactions, such as dystonia and Parkinsonism, caused by antipsychotics. Symptoms of Parkinson's disease and extrapyramidal reactions arise from decreases in dopaminergic activity which creates an imbala

3-(diphenylmethyl)oxy-8-methyl-8-azabicyclo[3.2.1]octane is a diarylmethane.

Benztropine mesylate Basic Attributes

Molecular Weight：

403.53

Exact Mass：

403.181732

EC Number：

205-048-8

HScode：

2933990090

Characteristics

PSA：

75.2

XLogP3：

4.94050

Appearance：

white to beige

Melting Point：

143 °C

Boiling Point：

547.8ºC at 760 mmHg

Flash Point：

285.1ºC

Water Solubility：

soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly).

Storage Conditions：

2-8°C

Vapor Pressure：

7.83E-13mmHg at 25°C

Safety Information

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

23/24/25

safety instructions：

36/37/39-45

RTECS Number：

YM3150000

Marks：

Precautionary statement(s)：

Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233

Hazard Statements：

H301 + H311 + H331

Drug Information

MeSH Entry Terms：

3-alpha-diphenylmethoxytropane

Benztropine mesylate Use and Manufacturing

anticholinergic agent; antihistamine

Computed Properties

Molecular Weight:307.4
XLogP3:4.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:307.193614421
Monoisotopic Mass:307.193614421
Topological Polar Surface Area:12.5
Heavy Atom Count:23
Complexity:340
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is an anticholinergic drug, and its effects and applications are similar to those of trihexyphenidyl. It also has antihistamine and local anesthetic effects. It is clinically used for Parkinson's disease and Parkinson's symptoms caused by various causes, including reserpine and phenothiazines, and its efficacy is better than that of trihexyphenidyl.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Benztropine Hydrobromide Tablets
Ingredients	The main ingredient of this product is benztropine mesylate.
Indication	Extrapyramidal reactions caused by reserpine and phenothiazines (except tardive dyskinesia).
Specifications	1mg

Registered Holders

NAVINTA LLC

United States
Active
ARCH PHARMALABS LTD

United States
Active
FINE CHEMICALS CORP PTY LTD

United States
Active

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CAS No.: 132-17-2

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High purity Benztropine mesylate CAS NO.132-17-2

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