Aramite

334.86

334.86

404155

DTXSID3020097

Colorless liquid|Clear light-colored oil

29252900

64

4.82 (est)

1.145 g/cm³ @ Temp: 20 °C

-31.7 °C

175 °C @ Press: 0.1 Torr

211.6ºC

nD20 1.5100 to 1.5118; nD27 1.5075

In water, 0.59 mg/L at 25 deg C (est)

0-6°C

2.18X10-7 mm Hg at 25 deg C (est)

Oral-Rat LD50: 3900 mg/kg

Combustion produces toxic nitrogen oxide and sulfur oxide gas

Henry's Law constant = 1.90X10-7 atm cu m/mole at 25 °C (est)

DARK AMBER LIQUID /TECHNICAL PRODUCT/|INCOMPATIBLE WITH ALKALINE MATERIALS SUCH AS LIME OR BORDEAUX MIXTURE.|Hydroxyl radical reaction rate constant = 3.58X10-11 cu cm/molec-sec at 25 °C (est)

Noncorrosive

III

8

UN12083/PG2

2

11-36/37/38-48/20-62-40

53-16-36/37/39-45-36/37-24/25-23

F,Xn

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

TECHNICAL MATERIAL IS DECOMPOSED BY SUNLIGHT AND DEVELOPS ODOR OF SULFUR DIOXIDE. /TECHNICAL MATERIAL/

P280-P305 + P351 + P338-P337 + P313

H315-H319-H335-H336-H351-H373

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Mix aramite with excess CaO /calcium oxide/ or NaOH /sodium hydroxide/ and sand or other adsorbent in a pit or trench at least 0.5 m deep in a clay soil. NaOH (or Na2CO3) /sodium carbonate/ can also be added to the mixture to help speed the reactions when calcium oxide is used as the main alkali. The amt of calcium oxide or sodium hydroxide to use depends on the amt of pesticide to be disposed of and, to some extent, the concn of active ingredient in the pesticide and the actual chemical nature of the active ingredient. A practical guideline, in the absence of specific directions, is to use an approx vol or wt of alkali from one-half of to the same as that of the pesticide. For dilute formulations, such as a 1% soln or dust, the amt of calcium oxide or sodium hydroxide can be reduced by one-half. For very concn pesticides (over 80% active ingredient) the amt of calcium oxide or sodium hydroxide can be doubled, but the concn should be mixed first with water (or soapy water) before reaction with the alkali. For safety, a preliminary test should be made in which very small amt of the pesticide and alkali are mixed and observed briefly to make sure it does not react too vigorously. Sizeable quantities of pesticides can be disposed of in several smaller batches, rather than all at once, for added safety. Recommendable methods: Incineration, hydrolysis, landfill, & discharge to sewer. Peer review: Small amt when hydrolized can be flushed to sewer or landfilled. Large amt should be incinerated in a unit with effluent gas scrubbing. (Peer-review conclusions of an IRPTC expert consultation (May 1985))|PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/|For more Disposal Methods (Complete) data for ARAMITE (9 total), please visit the HSDB record page.

Incompatible with alkaline material such as lime or Bordeaux mixture (slaked lime and copper sulfate solution.).

National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Aramite (140-57-8) is delisted as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/append/appb.pdf]

|Danger|H315 (92.68%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P264, P273, P280, P281, P302+P352, P305+P351+P338, P308+P313, P321, P332+P313, P337+P313, P362, P391, P405, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H303: May be harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P281, P305+P351+P338, P308+P313, P312, P332+P313, P337+P313, P405, and P501

Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Wear splash-proof chemical goggles and face shield unless full face-piece respiratory protection is worn. Contact lenses should not be worn when working with this chemical. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.|PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

This chemical is a combustible liquid. Poisonous gases including chlorine and sulfur oxide are produced in fire. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. Containers may explode in fire. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Ventilate area of pill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.|PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": Vertical laminar-flow biological safety cabinets may be used for containment of in vitro procedures ... provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak-tight. Horizontal laminar-flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used ... Each cabinet or fume cupboard to be used ... should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air-flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/|For more Preventive Measures (Complete) data for ARAMITE (10 total), please visit the HSDB record page.

Irritant to eyes & skin ... .

moderately toxic

LD50 Rat oral 3900 mg/kg|LD50 Guinea pig oral 3900 mg/kg|LD50 Mouse oral 2000 mg/kg

Aramite's former production and use as an acaricide (miticide)(1) may have resulted in its direct release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.0X10+4(SRC), determined from a structure estimation method(2), indicates that aramite is expected to be immobile in soil(SRC). Volatilization of aramite from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.9X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Aramite is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.2X10-7 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data for aramite are not available(SRC, 2007).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.0X10+4(SRC), determined from a structure estimation method(2), indicates that aramite is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.9X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 1000(SRC), from an estimated log Kow of 4.8(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). Biodegradation data for aramite are not available(SRC, 2007).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), aramite, which has an estimated vapor pressure of 2.2X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase aramite is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase aramite may be removed from the air by wet or dry deposition(SRC). In hexane solution, aramite does not absorb UV irradiation above 290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(5).

The rate constant for the vapor-phase reaction of aramite with photochemically-produced hydroxyl radicals has been estimated as 3.58X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Aramite contains functional groups that may be susceptible to hydrolysis(3); however, insufficient data are available to predict the relative importance or occurrence of chemical or biological degradation processes in water. In hexane solution, aramite does not absorb UV irradiation above 290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(3).

An estimated BCF of 1000 was calculated for aramite(SRC), using an estimated log Kow of 4.8(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC), provided the compound is not metabolized by the organism(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of aramite can be estimated to be 2.0X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that aramite is expected to be immobile in soil.

The Henry's Law constant for aramite is estimated as 1.9X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that aramite is expected to be essentially nonvolatile from water surfaces(2). Aramite is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.2X10-7 mm Hg(SRC), determined from a fragment constant method(3).

Occupational exposure and general population exposure should be low or non-existent since aramite has been discontinued and currently has little commercial interest. In the past, aramite was applied directly to citrus fruits as an acaricide, and exposure to this compound was primarily through sprays and dusts in the field where it was applied. (SRC)|No data are available on the number of workers who were actually or potentially exposed to aramite during its manufacture & formulation.

IT MAY CONTAIN 5-10% OF BIS-2(4-TERT-BUTYLPHENOXY)-1-METHYLETHYL SULFITE. /TECHNICAL PRODUCT/

Carcinogens

Skin decontamination. Skin contamination should be treated promptly by washing with soap and water. Contamination of the eyes should be treated immediately by prolonged flushing of the eyes with large amounts of clean water. If dermal or ocular irritation persists, medical attention should be obtained without delay. /Other herbicides/|Gastrointestinal decontamination. Ingestions of these herbicides are likely to be followed by vomiting and diarrhea due to their irritant properties. Management depends on: (1) the best estimate of the quantity ingested, (2) time elapsed since ingestion, and (3) the clinical status of the subject. Activated charcoal is probably effective in limiting irritant effects and reducing absorption of most or all of these herbicides. Aluminum hydroxide antacids may be useful in neutralizing the irritant actions of more acidic agents. Sorbitol should be given to induce catharsis if bowel sounds are present and if spontaneous diarrhea has not already commenced. Dehydration and electrolyte disturbances may be severe enough to require oral or intravenous fluids. ... If large amounts of herbicide have been ingested and the patient is seen within an hour of the ingestion, gastrointestinal decontamination should be considered ... . If the amount of ingested herbicides was small, if effective emesis has already occurred, or if treatment is delayed, administer activated charcoal and sorbitol by mouth. /Other herbicides/|Intravenous fluids. If serious dehydration and electrolyte depletion have occurred as a result of vomiting and diarrhea, monitor blood electrolytes and fluid balance and administer intravenous infusions of glucose, normal saline, Ringer's solution, or Ringer's lactate to restore extracellular fluid volume and electrolytes. Follow this with oral nutrients as soon as fluids can be retained. /Other herbicides/|Supportive measures are ordinarily sufficient for successful management of excessive exposures to these herbicides ... . If the patient's condition deteriorates in spite of good supportive care, the operation of an alternative or additional toxicant should be suspected. /Other herbicides/|For more Antidote and Emergency Treatment (Complete) data for ARAMITE (6 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ In undiluted form /it/ may cause skin irritation.

Aramite

LIQ CONCENTRATE (90%), FOR PAINTING HOT WATER PIPES; EMULSIFIABLE LIQ (204 LB/US GALLON); DISPERSIBLE POWDERS (USUALLY 15%); DUSTS (USUALLY 3%).|ARAMITE WAS FORMERLY AVAILABLE IN US AS A TECHNICAL GRADE PRODUCT CONTAINING 90% ACTIVE INGREDIENT. IT WAS ALSO OFFERED FOR SALE AS AN 85% EMULSIFIABLE CONCENTRATE, AS A 15% WETTABLE POWDER ... .|TECHNICAL: ... AT LEAST 90% PURITY.

This product was voluntarily cancelled on the basis of oncogenicity according to US EPA in a notice dated April 12, 1977.|INCOMPATIBLE WITH ALKALINE MATERIALS SUCH AS LIME OR BORDEAUX MIXTURE.|ARAMITE /PRODUCTION/ DISCONTINUED BY UNIROYAL.|RESIDUAL ACTION EFFECTIVE FOR SOME 7 DAYS.|Prepn: Harris et al, US patent 2,529,494 (1950 to US Rubber).

Aramite is stripped from sample /of food/ with benzene, soln is concentrated & Aramite is hydrolyzed with potassium hydroxide-isopropanol to form ethylene oxide. Evolved ethylene oxide is converted to formaldehyde with potassium iodate, & formaldehyde is reacted with acetylacetone to form colored cmpd which is determined colorimetrically. See 29.067-29.071, 12th edition.|GAS-LIQ CHROMATOGRAPHY METHOD FOR DETERMINING ARAMITE IN PRESENCE OF DDT, TOXAPHENE & ENDRIN IN CROP RESIDUES.|Method: EPA-EAD 1625; Procedure: gas chromatography/mass spectrometry; Analyte: aramite; Matrix: water; Detection Limit: not provided.|Method: EPA-OSW 8270D; Procedure: gas chromatography/mass spectrometry; Analyte: aramite; Matrix: solid waste matrices, soils, air sampling media and water samples; Detection Limit: 20 ug/L.

Agrochemicals -> Insecticides|Food Contaminant -> CONTAMINANT; -> JECFA Functional Classes|Health Hazards -> Carcinogens|ACARICIDES

Food Contaminant -> CONTAMINANT;