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Home > Encyclopedia > Piperazine adipate

Piperazine adipate

pharmaceutical raw materials
Piperazine adipate structure

Piperazine adipate 

structure
  • CAS No:

    142-88-1

  • Formula:

    C6H10O4.C4H10N2

  • Chemical Name:

    Piperazine adipate

  • Synonyms:

    Hexanedioic acid,compd. with piperazine (1:1);Adipic acid,compd. with piperazine (1:1);Piperazine,adipate (1:1);Piperazine,hexanedioate (1:1);Adiprazine;Arduvermin;Dietelmin;Entacyl;Helmirazin;Oxurasin;Oxyzin;Piperascat;Piperaskat;Piperazine adipate;Vermicompren;Piperazine adipinate;Nometan;Vermilass;Oxypaat;Pipadox;Adiprazina;Piperazinium adipate;NSC 74383;93505-75-0

  • Categories:

    Active Pharmaceutical Ingredients  >  Antiparasitic Drugs

Description

Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.


Piperazine adipate appears as odorless white crystalline powder or solid. Slightly acid taste. Melting point 256-257°C. Dissolves slowly. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6. (NTP, 1992)


Piperazine adipate appears as odorless white crystalline powder or solid. Slightly acid taste. Melting point 256-257°C. Dissolves slowly. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6. (NTP, 1992)|Piperazine adipate is a piperazinium salt obtained by combining equimolar amounts of piperazine and adipic acid. It has a role as an anthelminthic drug and an antinematodal drug. It contains an adipate(2-) and a piperazinium(2+).

Piperazine adipate Basic Attributes

232.28

232.14200

205-569-0

V7P5P122LB

74383

DTXSID2059724

2933599090

Characteristics

98.66000

0.55280

Piperazine adipate appears as odorless white crystalline powder or solid. Slightly acid taste. Melting point 256-257°C. Dissolves slowly. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6. (NTP, 1992)

256-257 °C

338.5ºC at 760 mmHg

172.7ºC

H2O: almost transparency

Water soluble.

Salts, Acidic

PIPERAZINE ADIPATE gives weakly acidic aqueous solutions. Can serve as both an oxidizing agent and as a reducing agent.

Safety Information

NONH for all modes of transport

MO1955000

Stable. Combustible. Incompatible with strong oxidizing agents. May be light-sensitive.

P260, P261, P264, P271, P272, P273, P280, P285, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P310, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, P501

H314

Flash point data for this chemical are not available; however it is probably combustible. (NTP, 1992)

|Danger|H314 (50%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P261, P264, P271, P272, P273, P280, P285, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P310, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this chemical can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

SYMPTOMS: Symptoms of prolonged exposure to this chemical include dizziness, vomiting, blurred vision, muscular incoordination and paresthesia. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes such as NOx. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

piperazine adipate

Piperazine adipate Use and Manufacturing

Uses

It is used as an anthelmintic for humans and farm animals against intestinal roundworms and pinworms infection

Hexanedioic acid, compd. with piperazine (1:1): INACTIVE

Computed Properties

Molecular Weight:232.28
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:232.14230712
Monoisotopic Mass:232.14230712
Topological Polar Surface Area:98.7
Heavy Atom Count:16
Complexity:140
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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