6-Methyl-2-pyridinemethanol
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6-Methyl-2-pyridinemethanol
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CAS No:
1122-71-0
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Formula:
C7H9NO
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Chemical Name:
6-Methyl-2-pyridinemethanol
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Synonyms:
2-Pyridinemethanol,6-methyl-;6-Methyl-2-pyridinemethanol;6-Methyl-2-pyridylmethanol;2-(Hydroxymethyl)-6-methylpyridine;6-Methyl-2-(hydroxymethyl)pyridine;NSC 164957;NSC 66528;(6-Methyl-2-pyridinyl)methanol;2-Methyl-6-pyridinemethanol
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CAS No:
Description
Clear light brown liquid or low melting solid
6-methyl-2-pyridinemethanol is a member of methylpyridines.
Characteristics
33.1
0.4
Clear light brown liquid or low melting solid
1.0877 (rough estimate)
96 °C
130-132 °C @ Press: 8 Torr
228 °F
1.5380 (estimate)
Low soluble in water, high soluble in ethanol, acetic acid. Soluble in benzene, toluene.
Refrigerator
0.0883mmHg at 25°C
Safety Information
NONH for all modes of transport
3
36/37/38-20/21/22
26-36-37/39-36/37/39
Xi,Xn
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
6-Methyl-2-pyridinemethanol Use and Manufacturing
(a) adding glacial acetic acid into the reaction bottle, adding 2, 6-lutidine, heating and mixing uniformly, wherein the mass ratio of glacial acetic acid to 2, 6-lutidine is 2.5: 1;(b) hydrogen peroxide (volume fraction of 28percent) and the catalyst sequentially added to the reaction flask of step (a), the reaction 3 hours, Wherein the catalyst is tungsten oxide, which is added in an amount of 5percent of the mass of 2, 6-lutidine and the amount of the hydrogen peroxide is 1.5 times of the mass of 2, 6-lutidine;(c) adding an equal amount of hydrogen peroxide (volume fraction of 28percent) in step (b) to a reaction flask for 7 hours;(d) After the reaction in step (c) is completed, the reaction mixture is distilled under reduced pressure to collect a fraction of 130-150 ° C / 12 mmHg;(e) refluxing the fraction obtained in the step (d) with acetic anhydride (the volume fraction of the fraction and the acetic anhydride is 0.7), ending the reaction to recover the glacial acetic acid to dry, the mother liquor and the alkali solution (10percent Potassium solution) was refluxed for 8 hours, the volume fraction of the fraction and potassium hydroxide solution was 1: 3, and then cooled to room temperature; (f) countercurrently extracting the refluxing reaction solution in step (e) with twice the volume of methylene chloride six times, combining the extracts, Dichloromethane was recovered by distillation to give 6-methyl-2-pyridylmethanol.In this embodiment, the yield of the reaction product 6-methyl-2-pyridylmethanol is 94percent and the selectivity of the reaction is as high as 95.2percent. The purity of the final product obtained after analysis is 99.1percent, which fully satisfies the requirements of the pharmaceutical manufacturing enterprises Synthesis needs.A glass reaction vessel was charged with 47.3 mg of Catalyst D, 123.4 mg (1.0 mmol) of benzyl methyl ether, 15.5 mg (0.08 mmol) of TsOH.H
Computed Properties
Molecular Weight:123.15
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:123.068413911
Monoisotopic Mass:123.068413911
Topological Polar Surface Area:33.1
Heavy Atom Count:9
Complexity:85
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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