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8-BROMO-4-CHLORO-2-METHYLQUINOLINE

8-BROMO-4-CHLORO-2-METHYLQUINOLINE structure

CAS No:
1201-07-6
Formula:
C10H7BrClN
Chemical Name:
8-BROMO-4-CHLORO-2-METHYLQUINOLINE
Synonyms:
8-Bromo-4-chloro-2-methylquinoline;Quinoline, 8-bromo-4-chloro-2-methyl-;SCHEMBL317207;CTK4B1686;DTXSID20354310;HMS1683B15;ZINC247826;3480AA;ANW-57911;SBB101769

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8-BROMO-4-CHLORO-2-METHYLQUINOLINE Basic Attributes

Molecular Weight：

256.527

Exact Mass：

254.945038

DSSTox ID：

DTXSID20354310

HScode：

2933499090

Characteristics

PSA：

12.9

XLogP3：

3.9

Density：

1.6±0.1 g/cm3

Flash Point：

148.5±26.5 °C

Refractive Index：

1.661

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

6.1

safety instructions：

26-39-45

Marks：

Precautionary statement(s)：

P280-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H318

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P280, P301+P310, P305+P351+P338, P310, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

8-BROMO-4-CHLORO-2-METHYLQUINOLINE Use and Manufacturing

Part A: To a quantity of 4.76 g (20 mmol) of 2-methyl-4-hydroxy-8-bromo-quinoline (J.Org.Chem. 1964, pg 3548) 15 ml of phosphorous oxychloride was added under ice-cooling. After heating to 100° C. for 30 minutes and subsequent cooling residual phosphorous oxychloride was removed by evaporation. After addition of ice water to the residue the mixture was neutralized with ammonia and extracted with CH2Cl2. The organic layer was dried over magnesium sulphate and concentrated in vacuo.The resulting product was purified on a silicagel column using ethylacetate as eluent.

Computed Properties

Molecular Weight:256.52
XLogP3:3.9
Hydrogen Bond Acceptor Count:1
Exact Mass:254.94504
Monoisotopic Mass:254.94504
Topological Polar Surface Area:12.9
Heavy Atom Count:13
Complexity:188
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 8-BROMO-4-CHLORO-2-METHYLQUINOLINE

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties

8-BROMO-4-CHLORO-2-METHYLQUINOLINE

SDS

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