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Netropsin

Netropsin structure

CAS No:
1438-30-8
Formula:
C18H26N10O3
Chemical Name:
Netropsin
Synonyms:
1H-Pyrrole-2-carboxamide,4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-;N,4′-Bi[pyrrole-2-carboxamide],N′-(2-amidinoethyl)-4-(2-guanidinoacetamido)-1,1′-dimethyl-;1H-Pyrrole-2-carboxamide,4-[[[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-;Congocidine;4-[[2-[(Aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-1H-pyrrole-2-carboxamide;IA 887;Congocidin;Sinanomycin;T 1384;Netropsin;NSC 3067;NCI 3067;554-32-5;1403-42-5;47686-02-2
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.

Netropsin Basic Attributes

Molecular Weight：

430.46

Exact Mass：

430.46

UNII：

64B3O0RD7N

DSSTox ID：

DTXSID90417704

Characteristics

PSA：

208.93000

XLogP3：

1.62120

Appearance：

faint yellow powder

Density：

1.3374 (rough estimate)

Melting Point：

171-173 °C

Boiling Point：

544.74°C (rough estimate)

Refractive Index：

1.6500 (estimate)

Water Solubility：

H2O: 1 mg/mL

Storage Conditions：

−20°C

Toxicity：

LD50 oral in mouse: 300mg/kg

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

DW2973000

Marks：

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

MeSH Entry Terms：

Congocidine

Netropsin Use and Manufacturing

The n-methylpyrrole-containing oligopeptide binds to the AT-rich sequence of dsDNA, especially at small groove sites. In this way, it protects the region from DNase I and endonuclease cleavage, and also inhibits topoisomerase. Spinosyn disrupts the cell division cycle, prolongs the G phase, and stops division in the G phase. It has anti-bacterial, fungal, trypanosome, vaccinia virus, bacteriophage and other functions in medicine.

Computed Properties

Molecular Weight:430.5
XLogP3:-3.1
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:430.21893473
Monoisotopic Mass:430.21893473
Topological Polar Surface Area:211
Heavy Atom Count:31
Complexity:723
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes