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Metadoxine

Metadoxine structure

CAS No:
74536-44-0
Formula:
C8H11NO3.C5H7NO3
Chemical Name:
Metadoxine
Synonyms:
L-Proline,5-oxo-,compd. with 5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1);3,4-Pyridinedimethanol,5-hydroxy-6-methyl-,compd. with 5-oxo-L-proline (1:1);Metadoxine;Metadoxil;Metasin;Alcoliv
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.

Metadoxine Basic Attributes

Molecular Weight：

298.295

Exact Mass：

298.116486

EC Number：

277-913-8

UNII：

EJQ7M98H5J

ATC Code：

A - Alimentary tract and metabolism

HScode：

2936250000

Characteristics

PSA：

140

XLogP3：

-0.24140

Appearance：

Off-White Powder

Melting Point：

102-104ºC

Boiling Point：

491.9°C at 760 mmHg

Flash Point：

251.3ºC

Storage Conditions：

Refrigerator

Drug Information

MeSH：

Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism. (See all compounds classified as Alcohol Deterrents.)

MeSH Entry Terms：

Metadoxil

Metadoxine Use and Manufacturing

Metadoxine can be used for treating patients for liver functional disorders in performing stomatologic interventions and in treatment of acute and chronic alcoholism

Computed Properties

Molecular Weight:298.29
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:298.11648630
Monoisotopic Mass:298.11648630
Topological Polar Surface Area:140
Heavy Atom Count:21
Complexity:297
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Improve liver function damage caused by long-term drinking, resist hepatocyte lipid peroxidation, and reduce fat accumulation in hepatocytes of animals with chronic alcoholism

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Metadoxine Tablets
Ingredients	Main ingredient: Metadoxine. Chemical name: Pyridoxine L-2-pyrrolidone-5-carboxylate.
Indication	Metadoxine may increase the decarboxylation of peripheral levodopa and reduce its efficacy.
Specifications	0.5g
Manufacturer	Shandong Qidu Pharmaceutical Co., Ltd.

Metadoxine oral solution
Ingredients	Metadoxine.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	20ml:0.5g
Manufacturer	Yangtze River Pharmaceutical (Group) Co., Ltd.

Metadoxine Injection
Specifications	5ml: 0.3g
Manufacturer	Zhejiang Zhenyuan Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shandong Qidu Pharmaceutical Co., Ltd.

China
Active
Zhejiang Zhenyuan Pharmaceutical Co., Ltd.

China
Active

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