Olopatadine hydrochloride
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Olopatadine hydrochloride
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CAS No:
140462-76-6
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Formula:
C21H23NO3.ClH
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Chemical Name:
Olopatadine hydrochloride
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Synonyms:
Dibenz[b,e]oxepin-2-acetic acid,11-[3-(dimethylamino)propylidene]-6,11-dihydro-,hydrochloride (1:1),(11Z)-;Dibenz[b,e]oxepin-2-acetic acid,11-[3-(dimethylamino)propylidene]-6,11-dihydro-,hydrochloride,(Z)-;Dibenz[b,e]oxepin-2-acetic acid,11-[3-(dimethylamino)propylidene]-6,11-dihydro-,hydrochloride,(11Z)-;KW 4679;ALO 4943A;Olopatadine hydrochloride;Allelock;(Z)-11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-acetic acid hydrochloride;Patanase;Allerock;Patadine;Olopine;Olopax;Pazeo;Opatanol;Patanol;Pataday
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CAS No:
Description
Olopatadine HCl is a histamine blocker used to treat allergic conjunctivitis.Target: Histamine ReceptorOlopatadine is one of the second-generation histamine H1 receptor antagonists that are treated for allergic disorders. Olopatadine significantly inhibited the ear swelling and the increased production of IL-4, IL-1beta, IL-6, GM-CSF and NGF in the lesioned ear [1]. Olopatadine was highly and rapidly absorbed in healthy human volunteers. The urinary excretion of olopatadine accounted for
Characteristics
49.8
3.4
Solid
1.221 g/cm3
242-245°C
545.7°C at 760 mmHg
270.1ºC
H2O: ≥20mg/mL
Refrigerator
Olopatadine hydrochloride Use and Manufacturing
Olopatadine is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]
Drug Function and Efficacy
No specific pharmacological information is provided
Registered Holders
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Pcas
Active
United States
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Curia Spain S.A.U.
Active
Japan
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Beijing Alica Pharmaceutical Sci-Tech Co., Ltd.
Active
China
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