Promestriene
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Promestriene
structure -
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CAS No:
39219-28-8
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Formula:
C22H32O2
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Chemical Name:
Promestriene
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Synonyms:
Estra-1,3,5(10)-triene,17-methoxy-3-propoxy-,(17β)-;(17β)-17-Methoxy-3-propoxyestra-1,3,5(10)-triene;3-Propoxy-17β-methoxyestra-1,3,5(10)-triene;Promestriene
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Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System
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CAS No:
Characteristics
18.5
6.48
1.1±0.1 g/cm3
64-660C
436.8±45.0 °C at 760 mmHg
153.3±28.3 °C
1.546
-20°C Freezer
Safety Information
24/25
P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, P501
H302
Promestriene Use and Manufacturing
A synthetic diethyl-ether of Estradiol with no distal hormonal effects, in patients undergoing surgical correction for stress urinary incontinence (SUI).
Computed Properties
Molecular Weight:328.5
XLogP3:4.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:328.240230259
Monoisotopic Mass:328.240230259
Topological Polar Surface Area:18.5
Heavy Atom Count:24
Complexity:436
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Promestriene is a steroidal estrogen drug. Promestriene produces local estrogen effects in the mucosa at the bottom of the reproductive tract, thereby restoring its nutritional function. After being used in the vagina, it will not produce systemic estrogen effects on areas away from the vagina.
Registered Holders
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YABAO PHARMACEUTICAL GROUP CO LTD
Active
United States
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Qingdao Guohai Biopharmaceutical Co., Ltd.
Active
China
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Yabao Pharmaceutical Group Co., Ltd.
Active
China
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