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Deoxynojirimycin

Deoxynojirimycin structure

CAS No:
19130-96-2
Formula:
C6H13NO4
Chemical Name:
Deoxynojirimycin
Synonyms:
3,4,5-Piperidinetriol,2-(hydroxymethyl)-,(2R,3R,4R,5S)-;Glucopyranose,5-amino-1,5-dideoxy-,D-;3,4,5-Piperidinetriol,2-(hydroxymethyl)-,[2R-(2α,3β,4α,5β)]-;(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol;Nojirimycin,1-deoxy-;1-Deoxynojirimycin;D-Glucitol,1,5-dideoxy-1,5-imino-;Moranoline;5-Amino-1,5-dideoxy-D-glucopyranose;Moranolin;Deoxynojirimycin;BAY-h 5595;1,5-Dideoxy-1,5-imino-D-glucitol;D-1-Deoxynojirimycin;Duvoglustat;70956-02-4
Categories:
Pharmaceutical Intermediates > Blood Glucose Regulators

Description

1-Deoxynojirimycin (DNJ, Duvoglustat) is a potent α-glucosidase inhibitor, suppresses postprandial blood glucose, thereby possibly preventing diabetes mellitus. Target: α-glucosidase1-Deoxynojirimycin is an alpha-glucosidase inhibitor, most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes o

Solid

Deoxynojirimycin Basic Attributes

Molecular Weight：

163.17

Exact Mass：

163.17

EC Number：

2017-001-1

HScode：

2933399090

Characteristics

PSA：

XLogP3：

-2.3

Appearance：

White Powder

Density：

1.5±0.1 g/cm3

Melting Point：

204-205 °C

Boiling Point：

361°C at 760 mmHg

Flash Point：

197.3±18.5 °C

Refractive Index：

1.582

Water Solubility：

soluble in water, dimethyl sulfoxide and methanol.

Storage Conditions：

Desiccate at +4°C

Safety Information

wgk germany：

hazard class code：

R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

24/25

RTECS Number：

TN4350300

Marks：

Stability/Shelf Life：

Stable if stored as directed.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Drug Information

MeSH Entry Terms：

1-deoxy-nojirimycin

Deoxynojirimycin Use and Manufacturing

An inhibitor of α-glucosidase I and II

Computed Properties

Molecular Weight:163.17
XLogP3:-2.3
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:163.08445790
Monoisotopic Mass:163.08445790
Topological Polar Surface Area:93
Heavy Atom Count:11
Complexity:132
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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