Paeoniflorin
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Paeoniflorin
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CAS No:
23180-57-6
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Formula:
C23H28O11
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Chemical Name:
Paeoniflorin
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Synonyms:
β-D-Glucopyranoside,(1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl;Peoniflorin;β-D-Glucopyranoside,5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl,[1aR-(1aα,2β,3aα,5α,5aα,5bα)]-;2,5-Methano-1H-3,4-dioxacyclobuta[cd]pentalene,β-D-glucopyranoside deriv.;(1aR,2S,3aR,5R,5aR,5bS)-5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-D-glucopyranoside;Paeoniflorin;NSC 178886;101673-30-7;11031-03-1;31016-95-2;31098-63-2
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CAS No:
Description
Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.Target: OthersPaeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrog
Paeoniflorin is a terpene glycoside.|Peoniflorin is under investigation in clinical trial NCT02878863 (Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis).
Characteristics
164
-1.35750
white
1.6±0.1 g/cm3
approximate 124℃ (dec.)
683.3°C at 760 mmHg
238.4±25.0 °C
1.683
room temp
1.07E-19mmHg at 25°C
LD50 ipr-mus: 9530 mg/kg YKKZAJ 89,879,69
Safety Information
UN 3077 9/PG 3
2
R22:Harmful if swallowed. R50:Very Toxic to aquatic organisms. R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed
24/25
RT1200000
Xn,N,T,F
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)
paeoniflorin
Paeoniflorin Use and Manufacturing
Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin has broad pharmacological effects, such as analgesic, anti-diuretic，anti-inflammatory，anti-convulsant, vasodilatic, and etc. In a study, paeoniflorin effe
Computed Properties
Molecular Weight:480.5
XLogP3:-1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:7
Exact Mass:480.16316171
Monoisotopic Mass:480.16316171
Topological Polar Surface Area:164
Heavy Atom Count:34
Complexity:849
Defined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Anti-inflammatory and neuroprotective compound with potential skin-soothing effects
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