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Benzeneacetic acid, 3-benzoyl-α-methyl-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), (αS)-

Benzeneacetic acid, 3-benzoyl-α-methyl-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), (αS)- structure

CAS No:
156604-79-4
Formula:
C16H14O3.C4H11NO3
Chemical Name:
Benzeneacetic acid, 3-benzoyl-α-methyl-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), (αS)-
Synonyms:
Benzeneacetic acid,3-benzoyl-α-methyl-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1),(αS)-;Benzeneacetic acid,3-benzoyl-α-methyl-,(S)-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Benzeneacetic acid,3-benzoyl-α-methyl-,(αS)-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);1,3-Propanediol,2-amino-2-(hydroxymethyl)-,(S)-3-benzoyl-α-methylbenzeneacetate (salt);1,3-Propanediol,2-amino-2-(hydroxymethyl)-,(αS)-3-benzoyl-α-methylbenzeneacetate (salt);S-(+)-Ketoprofen trometamol;Dexketoprofen trometamol;(S)-Ketoprofen trometamol;Dexketoprofen Tromethamine salt;Enantyum
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Benzeneacetic acid, 3-benzoyl-α-methyl-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), (αS)- Basic Attributes

Molecular Weight：

375.418

Exact Mass：

375.168182

EC Number：

1312995-182-4

HScode：

2922199695

Characteristics

PSA：

141.08000

XLogP3：

1.46680

Melting Point：

104.8-105.1°

Boiling Point：

431.3ºC at 760 mmHg

Flash Point：

228.8ºC

Vapor Pressure：

3.32E-08mmHg at 25°C

Specific rotation：

D20 -5.2° (c = 1.47 in methanol)

Safety Information

GHS Classification：

|Danger|H301 (16.18%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 70 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

Adolquir

Benzeneacetic acid, 3-benzoyl-α-methyl-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), (αS)- Use and Manufacturing

Mild to moderate pain Musculo-skeltal pain Dysmenorrhea Dental pain

Computed Properties

Molecular Weight:375.4
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:375.16818752
Monoisotopic Mass:375.16818752
Topological Polar Surface Area:141
Heavy Atom Count:27
Complexity:385
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Nonsteroidal anti-inflammatory drugs have anti-inflammatory, analgesic and antipyretic effects, and their mechanism of action may be related to the inhibition of prostaglandin synthesis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dexketoprofen Tromethamine Capsules
Ingredients	Molecular weight: C20H25NO6
Indication	1. When drinking alcohol or taking it with other non-steroidal anti-inflammatory drugs, it will increase gastrointestinal adverse reactions and bleeding tendency. Long-term use with acetaminophen may increase the toxic side effects on the kidneys. 2. When used with anticoagulants such as heparin and dicoumarol, and platelet aggregation inhibitors, there is an increased risk of bleeding. 3. When used with furosemide, the latter's sodium excretion and antihypertensive effects are weakened. 4. When used with verapamil and nifedipine, the blood concentration of this product increases. 5. This product can increase the blood concentration of digoxin. When used together, it is necessary to pay attention to adjusting the dose of digoxin. 6. This product can enhance the effect of oral antidiabetic drugs. 7. When this product is used together with antihypertensive drugs, it can affect the latter's antihypertensive effect. 8. This product should not be used with probenecid, because the latter can significantly reduce the renal clearance rate (reduced by 66%) and protein binding rate (reduced by
Specifications	12.5mg (calculated as C16H14O3)
Manufacturer	Anguo Yadong Biological Pharmaceutical Co., Ltd.

Dexketoprofen Tromethamine Tablets
Ingredients	Dexketoprofen tromethamine.
Indication	(1) When used with alcohol or other non-steroidal anti-inflammatory drugs, it increases gastrointestinal adverse reactions and bleeding tendency. Long-term use with acetaminophen may increase toxic side effects on the kidneys. (2) When used with anticoagulants such as heparin and dicoumarol and platelet aggregation inhibitors, there is an increased risk of bleeding. (3) When used with furosemide, the latter's sodium excretion and antihypertensive effects are weakened. (4) When used with verapamil and nifedipine, the blood concentration of this product increases. (5) This product can increase the blood concentration of digoxin, and the dose of digoxin should be adjusted when used together. (6) This product can enhance the effect of oral antidiabetic drugs. (7) When used with antihypertensive drugs, this product may affect the latter's antihypertensive effect. (8) This product should not be used with probenecid, because the latter can significantly reduce the renal clearance of this product (reduced by 66%)
Specifications	12.5mg (calculated as C16H14O3)
Manufacturer	Hubei Allianz Pharmaceutical Co., Ltd.

Dexketoprofen tromethamine
Manufacturer	Huangshi Shixing Pharmaceutical Co., Ltd.

Registered Holders

METROCHEM API PRIVATE LTD

United States
Active
SCL LIFESCIENCES LTD

United States
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SNJ LIFECARE PVT LTD

United States
Active

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Guide of Benzeneacetic acid, 3-benzoyl-α-methyl-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), (αS)-

Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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Benzeneacetic acid, 3-benzoyl-α-methyl-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1), (αS)-

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