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Amoxicillin sodium

Amoxicillin sodium structure

CAS No:
34642-77-8
Formula:
C16H19N3O5S.Na
Chemical Name:
Amoxicillin sodium
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1),(2S,5R,6R)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt,[2S-[2α,5α,6β(S*)]]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-,monosodium salt,(-)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt,(2S,5R,6R)-;Na-6-[D(-)-α-Amino-p-hydroxyphenylacetamido]penicillanic acid;Sodium α-amino-p-hydroxybenzylpenicillin;Amoxicillin sodium;Sodium amoxycillin;Sodium amoxicillin;Amoxycillin sodium salt;Amoxycillin sodium;BRL 2333AB-B;26787-88-2
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Amoxicillin Sodium is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.Target: AntibacterialAmoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is susceptible to degradation

Amoxicillin sodium Basic Attributes

Molecular Weight：

388.39

Exact Mass：

387.086487

EC Number：

252-124-1

HScode：

2941109900

Characteristics

PSA：

161

XLogP3：

-0.28190

Appearance：

White or almost white crystalline powder

Melting Point：

130℃

Boiling Point：

743℃

Flash Point：

>110°(230°F)

Water Solubility：

soluble in water.

Safety Information

RTECS Number：

XH8300000

Amoxicillin sodium Use and Manufacturing

Methods of Manufacturing

Preparation of sterile Amoxicillin Sodium using methyl acetate as solvent; Amoxicillin trihydrate (50g) is dissolved in methyl acetate (92ml_), triethylamine (34g) and methanol (52m l_) . The resulting reaction solution is constantly stirred to a clear solution at temperature of 0-5

Uses

Broad-spectrum antibiotics.

Material

Amoxicillin

Amoxicillin trihydrate

Drug Function and Efficacy

Amoxicillin is a broad-spectrum penicillin antibiotic, which can be used in combination with potassium clavulanate to protect it from hydrolysis by β-lactamase. It has a good effect on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci, and also has good antibacterial activity against certain β-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Amoxicillin Sodium and Clavulanate Potassium for Injection
Ingredients	This product is a compound preparation, its components are amoxicillin sodium and clavulanate potassium, the ratio of the two is 5:1.
Indication	1 Aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2β), and the toxicity may also increase. 2 When this product is used in combination with allopurinol, the incidence of rash increases significantly, so the combination should be avoided. 3 This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4 When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5 This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives. 6 Chloramphenicol, erythromycin
Specifications	0.3 g (C16H19N3O5S 0.25 g and C8H9NO5 0.05 g)
Manufacturer	Qingzhou Yaowang Pharmaceutical Co., Ltd.

Amoxicillin Sodium for Injection
Ingredients	The main ingredient of this product is amoxicillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-[(R)-(-)-2-amino-2-(4-hydroxyphenyl)acetylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate sodium.
Indication	1. Probenecid competitively reduces the renal tubular secretion of this product. The simultaneous use of the two can cause an increase in the blood concentration of amoxicillin and a prolonged half-life. 2. Chloramphenicol, macrolides, sulfonamides and tetracyclines interfere with the antibacterial effect of amoxicillin in vitro, but its clinical significance is unclear.
Specifications	2.0g (calculated as C16H19N3O5S)
Manufacturer	Shanxi Zhendong Taisheng Pharmaceutical Co., Ltd.

Amoxicillin Sodium and Clavulanate Potassium for Injection
Ingredients	This product is a compound preparation, its components are amoxicillin sodium and clavulanate potassium, the ratio of the two is 5:1.
Indication	1 Aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2β), and the toxicity may also increase. 2 When this product is used in combination with allopurinol, the incidence of rash increases significantly, so the combination should be avoided. 3 This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4 When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5 This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives. 6 Chloramphenicol, erythromycin
Specifications	1.2g(C16H19N3O5S1g and C8H9NO50.2g)
Manufacturer	Hunan Kelun Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

APITORIA PHARMA PRIVATE LTD

United States
Active
Reyoung Pharmaceutical Co., Ltd.

China
Active
CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

China
Active

See More Registered Holders

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