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Tacrolimus hydrate

Tacrolimus hydrate structure

CAS No:
109581-93-3
Formula:
C44H69NO12.H2O
Chemical Name:
Tacrolimus hydrate
Synonyms:
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-,hydrate (1:1),(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-;Tsukubaenolide hydrate;Tacrolimus hydrate;Tacforius
Categories:
Biochemical Engineering > Inhibitors

Description

Tacrolimus monohydrate binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus monohydrate is a mTOR-independent autophagy inducer.

Tacrolimus hydrate Basic Attributes

Molecular Weight：

822.04

Exact Mass：

821.492554

Characteristics

PSA：

179

XLogP3：

log Kow = 3.03 (est)

Melting Point：

127-129°

Boiling Point：

871.7°C at 760 mmHg

Flash Point：

481ºC

Water Solubility：

DMSO: soluble 20mg/mL

Storage Conditions：

−20°C

Vapor Pressure：

8.37X10-32 mm Hg at 25 °C (est)

Specific rotation：

D23 -84.4° (c = 1.02 in chloroform)

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1

Transport codes：

UN28116.1/PG3

hazard class code：

safety instructions：

RTECS Number：

KD4201200

Marks：

Stability/Shelf Life：

Stable under recommended storage conditions. /FK-506 monohydrate/

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H301

Tacrolimus hydrate Use and Manufacturing

immune suppressant, antifungal

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Tacrolimus eye drops
Ingredients	Tacrolimus hydrate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.1% (5ml:5mg (in terms of tacrolimus)

Tacrolimus eye drops
Ingredients	The main ingredient of this product is tacrolimus hydrate.
Specifications	0.1% (5ml:5mg (as tacrolimus))

Registered Holders

Lunan New Time Bio-Tech Co., Ltd.

Japan
Active
TAPI Czech Industries s.r.o.

Czech
Active
CERES F&D INC.

South Korea
Active

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Recommended Suppliers of Tacrolimus hydrate

Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

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Provide High-Quality Pharmaceutical API Tacrolimus Monohydrate (USP Standard) CAS 109581-93-3

CAS No.: 109581-93-3

Grade: Pharmaceutical Grade

Content: 99%

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Tacrolimus monohydrate

CAS No.: 109581-93-3

Content: 99.00%

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