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Dabrafenib

Dabrafenib structure

CAS No:
1195765-45-7
Formula:
C23H20F3N5O2S2
Chemical Name:
Dabrafenib
Synonyms:
Benzenesulfonamide,N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenib;GSK 2118436;Dabarefenib;Tafinlar;GSK 436;N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Tafmlar
Categories:
Biochemical Engineering > Inhibitors

Description

Dabrafenib is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively.

Molecular Weight：

519.5624096

Exact Mass：

519.56

EC Number：

1592732-453-0

PSA：

148

XLogP3：

4.8

Density：

1.4±0.1 g/cm3

Boiling Point：

653.7±65.0°C at 760 mmHg

Flash Point：

349.2±34.3 °C

Refractive Index：

1.626

Water Solubility：

very slightly soluble at pH 1

PKA：

-1.5None

Precautionary statement(s)：

P201, P202, P260, P273, P281, P308+P313, P314, P391, P405, P501

Hazard Statements：

H361

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