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Rifamycin S

Rifamycin S structure

CAS No:
13553-79-2
Formula:
C37H45NO12
Chemical Name:
Rifamycin S
Synonyms:
Rifamycin,1,4-dideoxy-1,4-dihydro-1,4-dioxo-;2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone,5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-,21-acetate;Rifomycin S;2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan,rifamycin deriv.;1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin;Rifamycin S;NSC 144130;27184-20-9;959320-39-9;1217878-21-1
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Rifamycin S is a quinone and an antibiotic agnet against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy[1][2][3].

Semi-synthetic antibiotic.

Rifamycin S Basic Attributes

Molecular Weight：

695.76

Exact Mass：

695.75

EC Number：

236-938-4

HScode：

2941903000

Characteristics

PSA：

194.99000

XLogP3：

2.87

Appearance：

Yellow orange crystalline powder

Density：

1.3±0.1 g/cm3

Melting Point：

180-182 °C

Boiling Point：

917.4±65.0 °C at 760 mmHg

Flash Point：

508.6±34.3 °C

Refractive Index：

1.605

Vapor Pressure：

0mmHg at 25°C

Specific rotation：

D20 +476° (c = 0.1 in methanol)

Safety Information

RTECS Number：

KD1925000

GHS Classification：

|Warning|H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P301+P312, P309+P311, P330, P391, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Rifamycin S Use and Manufacturing

Semi-synthetic antibiotic.

Computed Properties

Molecular Weight:695.8
XLogP3:4.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:3
Exact Mass:695.29417587
Monoisotopic Mass:695.29417587
Topological Polar Surface Area:195
Heavy Atom Count:50
Complexity:1480
Defined Atom Stereocenter Count:9
Undefined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Synthesis Route

54356-09-1

Recommended Suppliers of Rifamycin S

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Rifamycin S

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CAS No.: 13553-79-2

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