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Azlocillin sodium

Azlocillin sodium structure

CAS No:
37091-65-9
Formula:
C20H23N5O6S.Na
Chemical Name:
Azlocillin sodium
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[[(2R)-2-[[(2-oxo-1-imidazolidinyl)carbonyl]amino]-2-phenylacetyl]amino]-,sodium salt (1:1),(2S,5R,6R)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[[[[(2-oxo-1-imidazolidinyl)carbonyl]amino]phenylacetyl]amino]-,monosodium salt,[2S-[2α,5α,6β(S*)]]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[[(2R)-[[(2-oxo-1-imidazolidinyl)carbonyl]amino]phenylacetyl]amino]-,monosodium salt,(2S,5R,6R)-;Sodium azlocillin;Azlocillin sodium;Azlocillin sodium salt;Securopen;Monosodium azlocillin;Azlin
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Azlocillin is an acylampicillin with a broad spectrum against bacteria.Target: AntibacterialAzlocillin (12.5 μg/mL) inhibits over 75% of the isolates of Pseudomonas aeruginosa. Azlocillin (12.5 μg/mL) is also active against indole-negative and -positive Proteus spp., inhibiting 98 and 71%, respectively. Azlocillin is more active than mezlocillin, ticarcillin, and carbenicillin and as active as BLP-1654 against isolates of P. aeruginosa [1]. The acyl side chains of Azlocillin have an urei

Azlocillin sodium Basic Attributes

Molecular Weight：

483.47

Exact Mass：

483.118835

EC Number：

253-347-7

HScode：

2942000000

Characteristics

PSA：

173

XLogP3：

0.2

Appearance：

Solid

Flash Point：

>110°(230°F)

Water Solubility：

Freely soluble in water:50mg/mL

Storage Conditions：

room temp

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

wgk germany：

hazard class code：

42/43

safety instructions：

RTECS Number：

XH9250000

Marks：

Precautionary statement(s)：

P261-P280-P342 + P311

Hazard Statements：

H317-H334

Azlocillin sodium Use and Manufacturing

Azlocillin is a semisynthetic penicillin and is a potent 1-lactam antibiotic. It is often used against Pseudomonas aeruginosa and has been used to develop novel antibiotic quantitation techniques

Drug Function and Efficacy

This product is a semi-synthetic penicillin, which has good antibacterial effect on Gram-positive bacteria, Gram-negative bacteria and Pseudomonas aeruginosa. It can produce synergistic effect when used in combination with amikacin, gentamicin and netilmicin.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Azlocillin Sodium for Injection
Ingredients	Azlocillin sodium
Indication	1. Antibiotics such as chloramphenicol, erythromycin, tetracyclines and antibacterial agents such as sulfonamides can interfere with the bactericidal activity of this product and should not be used in combination with this product, especially in the treatment of meningitis or serious infections that urgently require bactericides. 2. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product from the kidneys. Therefore, when used in combination with this product, its blood concentration will increase, the excretion time will be prolonged, and the toxicity may also increase. 3. This product is incompatible with heavy metals, especially copper, zinc and mercury, because the latter can destroy its oxidized thiazole ring. Rubber tubes or bottle stoppers made of zinc compounds can also affect its activity. Acidic glucose injection or tetracycline injection can destroy its activity. It can also be an oxidizing agent, a reducing agent or a hydroxylating agent.
Specifications	1.0g (calculated as C20H23N5O6S)

Azlocillin Sodium for Injection
Ingredients	Azlocillin sodium
Indication	1. Antibiotics such as chloramphenicol, erythromycin, tetracyclines and antibacterial agents such as sulfonamides can interfere with the bactericidal activity of this product and should not be used in combination with this product, especially in the treatment of meningitis or serious infections that urgently require bactericides. 2. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product from the kidneys. Therefore, when used in combination with this product, its blood concentration will increase, the excretion time will be prolonged, and the toxicity may also increase. 3. This product is incompatible with heavy metals, especially copper, zinc and mercury, because the latter can destroy its oxidized thiazole ring. Rubber tubes or bottle stoppers made of zinc compounds can also affect its activity. Acidic glucose injection or tetracycline injection can destroy its activity. It can also be an oxidizing agent, a reducing agent or a hydroxylating agent.
Specifications	2.0g
Manufacturer	Xinhua Pharmaceutical (Gaomi) Co., Ltd.

Azlocillin Sodium for Injection
Ingredients	Azlocillin sodium
Indication	1. Antibiotics such as chloramphenicol, erythromycin, tetracyclines and antibacterial agents such as sulfonamides can interfere with the bactericidal activity of this product and should not be used in combination with this product, especially in the treatment of meningitis or serious infections that urgently require bactericides. 2. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product from the kidneys. Therefore, when used in combination with this product, its blood concentration will increase, the excretion time will be prolonged, and the toxicity may also increase. 3. This product is incompatible with heavy metals, especially copper, zinc and mercury, because the latter can destroy its oxidized thiazole ring. Rubber tubes or bottle stoppers made of zinc compounds can also affect its activity. Acidic glucose injection or tetracycline injection can destroy its activity. It can also be an oxidizing agent, a reducing agent or a hydroxylating agent.
Specifications	2.0g
Manufacturer	Hainan Weikang Pharmaceutical(Qianshan) Co., Ltd.

See More Related Drugs

Registered Holders

Reyoung Pharmaceutical Co., Ltd.

China
Active
Xinhua Pharmaceutical (Gaomi) Co., Ltd.

China
Active
CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

China
Active

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Recommended Suppliers of Azlocillin sodium

Guangzhou Yaoguang Technology Co., Ltd. Contact Supplier

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37091-65-9 Azlocillin sodium

CAS No.: 37091-65-9

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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5 YRS

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Azlocillin sodium

CAS No.: 37091-65-9

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