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Fosfomycin tromethamine

Fosfomycin tromethamine structure

CAS No:
78964-85-9
Formula:
C4H11NO3.C3H7O4P
Chemical Name:
Fosfomycin tromethamine
Synonyms:
Phosphonic acid,P-[(2R,3S)-3-methyl-2-oxiranyl]-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Phosphonic acid,(3-methyloxiranyl)-,(2R-cis)-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Phosphonic acid,[(2R,3S)-3-methyloxiranyl]-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);1,3-Propanediol,2-amino-2-(hydroxymethyl)-,(2R-cis)-(3-methyloxiranyl)phosphonate (1:1) (salt);1,3-Propanediol,2-amino-2-(hydroxymethyl)-,[(2R,3S)-3-methyloxiranyl]phosphonate (1:1) (salt);Fosfomycin compd. with trometamol;Z 1282;Monuril;Fosfomycin trometamol salt;Tromethamine-fosfomycin;Fosfomycin trometamol;Fosfomycin tromethamine;Phosphonomycin monotrometamol;Monurol Sachet;Monurol;Fosfotricin;103485-19-4
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Fosfomycin tromethamine (MK-0955 tromethamine) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1].

An antibiotic produced by Streptomyces fradiae.

Fosfomycin tromethamine Basic Attributes

Molecular Weight：

259.19

Exact Mass：

259.082092

EC Number：

279-018-8

HScode：

2941906000

Characteristics

PSA：

166.58000

XLogP3：

-1.73000

Appearance：

white or off-white powder

Boiling Point：

357ºC at 760 mmHg

Flash Point：

169.7ºC

Water Solubility：

Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.

Safety Information

Transport codes：

NONH for all modes of transport

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Fosfomycin

Fosfomycin tromethamine Use and Manufacturing

Used as antibiotics

Computed Properties

Molecular Weight:259.19
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:259.08208891
Monoisotopic Mass:259.08208891
Topological Polar Surface Area:161
Heavy Atom Count:16
Complexity:190
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has antibacterial effects on gram-positive cocci such as Staphylococcus aureus and Staphylococcus epidermidis. It also has strong antibacterial activity against gram-negative bacteria such as Escherichia coli, Serratia, Shigella, Yersinia, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter aerogenes, Vibrio and Aeromonas. Fosfomycin can inhibit the early synthesis of bacterial cell walls. Its molecular structure is similar to phosphoenolpyruvate, so it can compete with bacteria for the same transferase, inhibiting bacterial cell wall synthesis and leading to bacterial death.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fosfomycin tromethamine powder
Ingredients	Fosfomycin tromethamine.
Indication	1. It has synergistic effect with beta-lactam antibiotics against Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus) and Pseudomonas aeruginosa. 2. It has synergistic effect with aminoglycoside antibiotics. 3. The in vitro antibacterial activity of this product is easily weakened by the interference of glucose or (and) phosphate in the culture medium. Adding a small amount of glucose-6-phosphate can enhance the effect of this product.
Specifications	3g (3 million units) (calculated as C3H704P)
Manufacturer	Hunan Warrant Pharmaceutical Co., Ltd.

Fosfomycin tromethamine
Manufacturer	NORTHEAST Pharmaceutical Group Co., Ltd.

Fosfomycin tromethamine
Manufacturer	Hunan Warrant Chiral Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

MSN ORGANICS PRIVATE LTD

United States
Active
HONOUR LAB LIMITED

India
Active
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

Italy
Active

See More Registered Holders

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