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Cefonicid sodium

Cefonicid sodium structure

CAS No:
61270-78-8
Formula:
C18H18N6O8S3.2Na
Chemical Name:
Cefonicid sodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-,sodium salt (1:2),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[(hydroxyphenylacetyl)amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-,disodium salt,[6R-[6α,7β(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-,disodium salt,(6R,7R)-;SKF 75073;Cefonicid sodium;Disodium cefonicid;Cefonicid disodium salt;Cefoplus;Monocid
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefonicid sodium is a broadspectrum cephalosporin antibiotic which inhibits the formation of the bacterial cell wall. Target: AntibacterialCefonicid sodium can inhibit the carnitine/carnitine antiport when it is added internally and externally to proteoliposomes. It is known that the molecule contains various electroactive groups that can be detected using adsorptive square-wave stripping voltammetry. In addition, the compound can be detected in solution using UV spectroscopy at 265 nm.

Cefonicid sodium is an organic sodium salt. It contains a cefonicid(2-).|Cefonicid Sodium is the sodium salt form of cefonicid, a semisynthetic second-generation cephalosporin with antibacterial activity. Cefonicid binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.|A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

Cefonicid sodium Basic Attributes

Molecular Weight：

586.53

Exact Mass：

585.998718

EC Number：

1592732-453-0

UNII：

F74MFL78A1

DSSTox ID：

DTXSID0046642

NCI Thesaurus Code：

C65300

HScode：

3003201900

Characteristics

PSA：

270

Melting Point：

> 160°C

Storage Conditions：

Store at 0-5°C

Collision Cross Section：

205.7 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

hazard class code：

6.1

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P342 + P311

Hazard Statements：

H317-H334

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Cefonicid

Cefonicid sodium Use and Manufacturing

Uses

Second-generation cephalosporins, suitable for Gram-positive and partially Gram-negative infections

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:586.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:7
Exact Mass:585.99871357
Monoisotopic Mass:585.99871357
Topological Polar Surface Area:270
Heavy Atom Count:37
Complexity:980
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefonicid Sodium
Manufacturer	China UNION Chempharma (SUZHOU) Co., Ltd.

Cefonicid Sodium for Injection
Ingredients	Cefonicid Sodium
Indication	When used together with nefrotossici drugs (such as antibiotics, etc.), renal function must be monitored at all times. 1. It cannot be administered in the same container as oxysugar drugs. 2. When used in combination with prilocaine, it can slow down renal excretion, increase blood drug concentration levels, and cause toxicity. 3. When used in combination with strong diuretics, it can lead to increased renal toxicity. 4. The effect of this drug can be reduced with tetracycline, erythromycin and chloramphenicol. 5. When used with alcohol at the same time, this drug may cause disorder reactions. 6. Cefuroxime can reduce the effect of oral contraceptives, and other effective contraceptive methods should be used. 7. Interference with laboratory test values, the false positive rate of coomds test is high.
Specifications	1.0g
Manufacturer	Anhu Welman Pharmaceut Icai Cd.ltd

Cefonicid Sodium for Injection
Ingredients	Cefonicid Sodium
Indication	When used together with nefrotossici drugs (such as antibiotics, etc.), renal function must be monitored at all times. 1. It cannot be administered in the same container as oxysugar drugs. 2. When used in combination with prilocaine, it can slow down renal excretion, increase blood drug concentration levels, and cause toxicity. 3. When used in combination with strong diuretics, it can lead to increased renal toxicity. 4. The effect of this drug can be reduced with tetracycline, erythromycin and chloramphenicol. 5. When used with alcohol at the same time, this drug may cause disorder reactions. 6. Cefuroxime can reduce the effect of oral contraceptives, and other effective contraceptive methods should be used. 7. Interference with laboratory test values, the false positive rate of coomds test is high.
Specifications	1.0g (calculated as C18H18N6O8S3)
Manufacturer	Haikou Pharmaceutical Factory Co., Ltd.

See More Related Drugs

Registered Holders

China UNION Chempharma (SUZHOU) Co., Ltd.

China
Active
Suzhou Wanqing Pharmaceutical Co., Ltd.

China
Active
Shandong Ruiying Pioneer Pharmaceutical Co., Ltd.

China
Active

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