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Cefamandole nafate

Cefamandole nafate structure

CAS No:
42540-40-9
Formula:
C19H18N6O6S2.Na
Chemical Name:
Cefamandole nafate
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-2-(formyloxy)-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:1),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt,[6R-[6α,7β(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt,(6R,7R)-;Cefamandole nafate;Sodium 7-(D-2-formyloxy-2-phenylacetamido)-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate;O-Formylcefamandole sodium;Cefamandole formate sodium;Cephamandole nafate;Mandol;Kefadol;Sodium O-formylcefamandole;Neocefal;Mandokef;Mandolsan;Cemandil;Pavecef;Kefandol;Bergacef;Cefiran;Cefam;Fado;Lampomandol;Cedol;Cemado;NSC 299588
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic.

Cefamandole nafate Basic Attributes

Molecular Weight：

512.49

Exact Mass：

512.054871

EC Number：

255-877-4

HScode：

3003201900

Characteristics

PSA：

210

XLogP3：

-0.41490

Appearance：

White solid

Melting Point：

190 °C (decomp)

Water Solubility：

Freely soluble in water. Sparingly soluble in methanol

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

26-36

RTECS Number：

XI0380000

Marks：

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311

Hazard Statements：

H315-H317-H319-H334-H335

Cefamandole nafate Use and Manufacturing

antibacterial

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefuroxime Sodium for Injection
Specifications	0.5g (calculated as C18H18N6O5S2)

Cefuroxime Sodium for Injection
Ingredients	The main ingredient of this product is cefuroxime sodium.
Indication	1. This product contains sodium carbonate, so it is incompatible with solutions containing calcium or magnesium (including compound sodium chloride injection or compound sodium lactate injection). The two cannot be mixed in the same container; if they must be used together, they should be administered separately in different containers. 2. The use of cefamandole with drugs that produce hypoprothrombinemia, thrombocytopenia or gastrointestinal ulcers will interfere with coagulation function and increase the risk of bleeding. 3. The use of cefamandole with aminoglycosides, polymyxins, furosemide, and ethacrynic acid may increase the possibility of nephrotoxicity. 4. Probenecid can inhibit the renal tubular secretion of cephalosporins. The simultaneous use of the two will increase the blood concentration of cephalosporins and prolong their half-life. 5. Erythromycin can increase the in vitro antibacterial activity of this product against Bacteroides fragilis by more than 100 times. When used in combination with gentamicin or amikacin, it has a synergistic effect against certain Gram-negative bacteria in vitro.
Specifications	2.0g (calculated as C18H18N6O5S2)
Manufacturer	Hainan Guangshengyu Pharmaceutical Co., Ltd.

Cefuroxime Sodium for Injection
Ingredients	The main ingredient of this product is ceftriaxone sodium, whose chemical name is 7-D-(2-formyloxyphenylacetamide)-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid sodium salt.
Indication	1. This product contains sodium carbonate, so it is incompatible with solutions containing calcium or magnesium (including compound sodium chloride injection or compound sodium lactate injection). The two cannot be mixed in the same container; if they must be used together, they should be administered separately in different containers. 2. The use of cefamandole with drugs that produce hypoprothrombinemia, thrombocytopenia or gastrointestinal ulcers will interfere with coagulation function and increase the risk of bleeding. 3. The use of cefamandole with aminoglycosides, polymyxins, furosemide, and ethacrynic acid may increase the possibility of nephrotoxicity. 4. Probenecid can inhibit the renal tubular secretion of cephalosporins. The simultaneous use of the two will increase the blood concentration of cephalosporins and prolong their half-life. 5. Erythromycin can increase the in vitro antibacterial activity of this product against Bacteroides fragilis by more than 100 times. When used in combination with gentamicin or amikacin, it has a synergistic effect against certain Gram-negative bacteria in vitro.
Specifications	0.5g (calculated as C18H18N6O5S2)
Manufacturer	Zhejiang Yongning Pharmaceutical Co., Ltd.

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Registered Holders

China UNION Chempharma (SUZHOU) Co., Ltd.

China
Active
Suzhou Wanqing Pharmaceutical Co., Ltd.

China
Active
Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

China
Active

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