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4-Hydroxycarbazole

4-Hydroxycarbazole structure

CAS No:
52602-39-8
Formula:
C12H9NO
Chemical Name:
4-Hydroxycarbazole
Synonyms:
9H-Carbazol-4-ol;4-Carbazolol;4-Hydroxycarbazole;SKF 106023;4-Hydroxy-9H-carbazole
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Light-Yellow Solid

4-Hydroxycarbazole Basic Attributes

Molecular Weight：

183.21

Exact Mass：

183.21

EC Number：

258-034-9

UNII：

3D95E7727V

DSSTox ID：

DTXSID60200584

HScode：

2933990090

Characteristics

PSA：

XLogP3：

3.5

Density：

1.4±0.1 g/cm3

Melting Point：

169-170 °C

Boiling Point：

431.4°C at 760 mmHg

Flash Point：

214.7±21.2 °C

Refractive Index：

1.815

Safety Information

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36-S37/39

Marks：

Xi:Irritant

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

4-hydroxycarbazole

4-Hydroxycarbazole Use and Manufacturing

Step 1: Preparation of 4-hydroxy carbazole; To a reactor containing water (1L) was added Raney nickel (35g) followed by 1, 2, 3, 9-tetrahydrocarbazole-4-one (50g) and sodium hydroxide (15g). The contents were heated to reflux and maintained for about 20 hours. The catalyst was filtered off and the filtrate was acidified to obtain a solid, which was filtered and dried to obtain the title compound. When necessary, the title compound was further purified by dissolving in 10percent sodium hydroxide solution, treating with activated charcoal and precipitation from dilute hydrochloric acid to give off-white to grey crystals of 4-hydroxy carbazole in 50percent yield.Example 6: 4-Hydroxycarbazole4-Hydroxycarbazole (Compound B) [475-010] was prepared by adding OHOC (compound I) (0.189 g, 1.00 mmol) to a solution of 0.330 g (5.00 mmol) of 85percent potassium hydroxide pellets in 3 mLH4-HydroxycarbazoleCompound I Compound B CPreparation 41 Preparation 48

Computed Properties

Molecular Weight:183.21
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Exact Mass:183.068413911
Monoisotopic Mass:183.068413911
Topological Polar Surface Area:36
Heavy Atom Count:14
Complexity:218
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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4-Hydroxycarbazole

CAS No.: 52602-39-8

Content: 99.00%

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