Cefpirome sulfate
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Cefpirome sulfate
structure -
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CAS No:
98753-19-6
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Formula:
C22H23N6O5S2.HO4S
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Chemical Name:
Cefpirome sulfate
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Synonyms:
5H-Cyclopenta[b]pyridinium,1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-,sulfate (1:1);HR 810 sulfate;Cefpirome sulfate;Keiten;Broact;128401-54-7;92682-19-4;160888-38-0
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CAS No:
Characteristics
208
0.29410
White or off white crystalline powder
>200 °C
soluble in DMSO
Store at 0-5°C
25D -4.7° (c = 5 in H2O)
Cefpirome sulfate Use and Manufacturing
The method for synthesizing cefpirome sulfuric acid by microwave method according to the present invention, Comprising the steps of:(1) 7-aminocephalosporanic acid (2.72 g, 7-ACA, Compound I, MW272, 0.01 mol) and AE-activity(AEMA, Compound VII, MW 350, 0.011 mol) was mixed and homogeneously ground.(Compound IV, MW 119, 0.011 mol) and concentrated sulfuric acid (10.88 g, 98percent by weight) were added to the solution, followed by the addition of 2, 30 g of 2, 3-cyclopentenopyridine.(2) 300W microwave reaction for 1 minute, 450W microwave reaction for 1 minute, 750W microwave reaction for 2 minutes;(3) After completion of the reaction, The reaction residue was added to 29.92 g of deionized water, Mixing and filtering, Take filtrate, The solvent was removed, A white solid, 50 & lt; 0 & gt; C for 4 hours under vacuum, That is to get the cefpirome sulfuric acid 5.09g (MW514), Yield 99.0percentPurity 99.9percent or more.
Fourth generation cephalosporin antibiotic
Drug Function and Efficacy
This product is a β-lactamase-stable cephalosporin bactericidal antibiotic. It works by blocking the synthesis of the main cell wall polymer, peptidoglycan. Because it can quickly penetrate the bacterial cell wall and bind to the target enzyme (penicillin binding protein) with high affinity, it can kill a wide spectrum of Gram-negative and Gram-positive pathogens at low concentrations.
Registered Holders
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Reyoung Pharmaceutical Co., Ltd.
Active
China
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China UNION Chempharma (SUZHOU) Co., Ltd.
Active
China
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Suzhou Wanqing Pharmaceutical Co., Ltd.
Active
China
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