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Dibucaine hydrochloride

Dibucaine hydrochloride structure

CAS No:
61-12-1
Formula:
C20H30ClN3O2
Chemical Name:
Dibucaine hydrochloride
Synonyms:
2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid;Dibucaine (Cinchocaine) HCl;2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamidmonohydrochloride;2-butoxy-n-(2-diethylaminoethyl)cinchoninicacidamidehydrochloride;2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamidehydrochloride;4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-,monohydrochloride;benzolin(localanesthetic);butoxycinchoninicaciddiethylethylenediamidehydrochloride
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Dibucaine Hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia.Target: Sodium ChannelDibucaine is an amide local anesthetic. Dibucaine reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain [1].Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a rever

white powder

ChEBI: The monohydrochloride salt of cinchocaine. It is used in creams, ointments and suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.

Poison by ingestion,subcutaneous, intravenous, intraspinal, parenteral, andintraperitoneal routes. Mutation data reported. A severeeye irritant. A local anesthetic. When heated todecomposition it emits very toxic fumes of HCl and NOx

Dibucaine hydrochloride Basic Attributes

Molecular Weight：

379.92

Exact Mass：

379.202667

EC Number：

200-498-1

UNII：

Z97702A5DG

NSC Number：

756724

Color/Form：

Hygroscopic crystals

HScode：

2933492250

Characteristics

PSA：

54.5

XLogP3：

4.67820

Density：

1.1338 (rough estimate)

Melting Point：

99-101 °C(lit.)

Boiling Point：

496.3ºC at 760 mmHg

Flash Point：

254ºC

Refractive Index：

1.5400 (estimate)

Water Solubility：

Freely soluble in water, alcohol, acetone, or chloroform

Storage Conditions：

Refrigerator

Toxicity：

eye-rbt 2% SEV ARZNAD 8,181,58

PH：

pH(20g/l,25℃) : 5.0～6.0

Collision Cross Section：

195.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Critical Temperature & Pressure：

Refrigerator

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

26-39

RTECS Number：

GD3325000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents. Protect from moisture.

Precautionary statement(s)：

P280-P305 + P351 + P338

Hazard Statements：

22-41

GHS Classification：

|Danger|H302 (96.95%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P333+P313, P363, P391, and P501|Aggregated GHS information provided by 131 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Exposure Prevention：

Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.

Dibucaine hydrochloride Use and Manufacturing

Uses

Anesthetic (local).

Cinchocaine is used as an anaesthetic agent for spinal anaesthesia; a component in rectal medications used in inflammation of the anus and for the symptomatic treatment of hemorrhoids and fissures in the anus; local anesthetic agent.

Dibucaine HCl is an amide-like quinoline derivative and is one of the most potent and longest acting of the commonly used local anesthetics.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:379.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:379.2026549
Monoisotopic Mass:379.2026549
Topological Polar Surface Area:54.5
Heavy Atom Count:26
Complexity:387
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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