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Prilocaine hydrochloride

Prilocaine hydrochloride structure

CAS No:
1786-81-8
Formula:
C13H20N2O.ClH
Chemical Name:
Prilocaine hydrochloride
Synonyms:
Propanamide,N-(2-methylphenyl)-2-(propylamino)-,hydrochloride (1:1);o-Propionotoluidide,2-(propylamino)-,monohydrochloride;Propanamide,N-(2-methylphenyl)-2-(propylamino)-,monohydrochloride;Citanest hydrochloride;L 67 hydrochloride;α-(Propylamino)-2-methylpropionanilide hydrochloride;2-(Propylamino)-o-propionotoluidide hydrochloride;Prilocaine hydrochloride;Propitocaine hydrochloride;Xylonest;Prilocaine chloride;Citanest Plain;L 67;2-(Propylamino)-N-(o-tolyl)propanamide hydrochloride;88208-29-1
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

White SolidChEBI: The monohydrochloride salt of prilocaine.

A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.

Prilocaine hydrochloride Basic Attributes

Molecular Weight：

256.77

Exact Mass：

256.134247

EC Number：

217-244-0

NSC Number：

758432

DSSTox ID：

DTXSID2031956

HScode：

29242990

Characteristics

PSA：

41.1

XLogP3：

3.58750

Appearance：

White or off white crystalline powder

Melting Point：

167-168 °C

Boiling Point：

85°C 4mm

Flash Point：

134.3ºC

Water Solubility：

Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone

Storage Conditions：

Refrigerator

Vapor Pressure：

2.05E-05mmHg at 25°C

Collision Cross Section：

154.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

UG5775000

Precautionary statement(s)：

P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, and P501|Aggregated GHS information provided by 68 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

MeSH Entry Terms：

Citanest

Prilocaine hydrochloride Use and Manufacturing

Uses

Anesthetic (local).

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:256.77
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:256.1342410
Monoisotopic Mass:256.1342410
Topological Polar Surface Area:41.1
Heavy Atom Count:17
Complexity:218
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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