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Diclazuril

Diclazuril structure

CAS No:
101831-37-2
Formula:
C17H9Cl3N4O2
Chemical Name:
Diclazuril
Synonyms:
Benzeneacetonitrile,2,6-dichloro-α-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-;2,6-Dichloro-α-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile;R 64433;Diclazuril;Clinacox;P 64433;Vecoxan;Nuoqiu;2-(4-Chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Off-White SolidDiclazuril (molecular formula: C17H9Cl3N4O2, Trade name: Vecoxan) belongs to a kind of coccidiostat and potent antiprotozoal agents. It is mainly used for the treatment, control, prevention and improvements of Coccidal infections. It alleviates the symptoms of the patients by interrupting the life cycle of the parasites. It induces the morphological changes and attenuates the mitochondrial transmembrane potential in meroites. It can prevent congenital toxoplasmosis and have antic

2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile is a nitrile.|Diclazuril is a coccidiostat.

Diclazuril Basic Attributes

Molecular Weight：

407.64

Exact Mass：

407.64

EC Number：

1806241-263-5

NSC Number：

759642

DSSTox ID：

DTXSID4046787

HScode：

29336990

Characteristics

PSA：

85.6

XLogP3：

4.1

Appearance：

yellowish or white powder

Density：

1.56±0.1 g/cm3(Predicted)

Melting Point：

290.5°

Refractive Index：

1.701

Storage Conditions：

0-6°C

Safety Information

Packing level：

Ⅲ

Transport codes：

3077

wgk germany：

hazard class code：

safety instructions：

24/25

RTECS Number：

CY1697600

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Precautionary statement(s)：

P273, P391, P501

Hazard Statements：

H400

GHS Classification：

|Warning|H361 (79.55%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P260, P273, P281, P308+P313, P314, P391, P405, and P501|Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)

MeSH Entry Terms：

2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile

Diclazuril Use and Manufacturing

Uses

antiprotozoal

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Veterinary Drug -> ANTIPROTOZOAL_AGENT; -> JECFA Functional Classes|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Food Additive Classes：

Veterinary Drug -> ANTIPROTOZOAL_AGENT;

Computed Properties

Molecular Weight:407.6
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:405.979109
Monoisotopic Mass:405.979109
Topological Polar Surface Area:85.6
Heavy Atom Count:26
Complexity:629
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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