Etidronate disodium
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Etidronate disodium
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CAS No:
7414-83-7
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Formula:
C2H8O7P2.2Na
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Chemical Name:
Etidronate disodium
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Synonyms:
Phosphonic acid,P,P′-(1-hydroxyethylidene)bis-,sodium salt (1:2);Phosphonic acid,(1-hydroxyethylidene)di-,disodium salt;Phosphonic acid,(1-hydroxyethylidene)bis-,disodium salt;Sodium ethane-1-hydroxy-1,1-diphosphonate;Disodium etidronate;Sodium ethydronate;Disodium ethane-1-hydroxy-1,1-diphosphonic acid;Disodium 1-hydroxy-1,1-ethanediphosphonate;Sodium etidronate;Disodium 1-hydroxyethylidenediphosphonate;Disodium ethane-1-hydroxy-1,1-diphosphonate;Disodium (1-hydroxyethylidene)-1,1-diphosphonate;Disodium ethane-1-hydroxy-1-diphosphonate;Disodium 1-hydroxyethanediphosphonate;Disodium ethanol-1,1-diphosphonate;Disodium 1-hydroxyethane-1-diphosphonate;1-Hydroxyethane-1,1-diphosphonic acid disodium salt;Etidronate disodium;Sodium ethidronate;Disodium ethydronate;Disodium (1-hydroxyethylidene)-1,1-bisphosphonate;Didronel R;Sequion 10Na2;Didronel;Turpinal 2NZ;Ostedron;BA 49280E;Fostex NZ 2;Etidron;Calcimux;Etidronic acid disodium salt;Chelest PH 212;Xydifon;TF 133B;TF 133B (chelating agent);Chelest PH 210;PH 212;Cublen K 2012;Disodium HEDP;Hydroxyethylidene diphosphonic acid disodium salt;Disodium hydroxy-[1-hydroxy-1-(hydroxy-oxidophosphoryl)ethyl]phosphinate;Disodium hydroxyethylidene diphosphonate;187285-10-5;1159812-97-1;1338481-55-2
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CAS No:
Characteristics
141
-0.11580
white solid
>300 °C
578.8ºC at 760 mmHg
303.8ºC
soluble in water (26 mg/ml).
2-8°C
Safety Information
NONH for all modes of transport
1
22
36/37/39
SZ8562240
Xn
P301 + P312 + P330
H302
|Warning|H302 (64.25%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, and P501|Aggregated GHS information provided by 305 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501
Etidronate disodium Use and Manufacturing
Sequestering and chelating agent; scale and corrosion inhibitor.
Functional fluids (closed systems)
Fabric, textile, and leather products not covered elsewhere
100,000 - 500,000 lb
All other chemical product and preparation manufacturing|Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2): ACTIVE
Computed Properties
Molecular Weight:268.01
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:1
Exact Mass:267.94897977
Monoisotopic Mass:267.94897977
Topological Polar Surface Area:142
Heavy Atom Count:14
Complexity:223
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a bone metabolism regulator. It has a strong affinity for calcium phosphate in the body, can inhibit abnormal calcification and excessive bone absorption in the human body, relieve bone pain, reduce the concentration of serum alkaline phosphatase and urinary hydroxyproline; at low doses, it can directly inhibit osteoclast formation and prevent bone absorption, reduce bone turnover rate, increase bone density, etc. to achieve bone calcium regulation.
Registered Holders
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Zhejiang Hisun Pharmaceutical Co., Ltd.
Active![China]()
China
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Sichuan Rainbow Pharmaceutical Co., Ltd.
Active![China]()
China
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Yangzhou Zhongbao Pharmaceutical Co., Ltd.
Active![China]()
China
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