Abiraterone acetate
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Abiraterone acetate
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CAS No:
154229-18-2
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Formula:
C26H33NO2
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Chemical Name:
Abiraterone acetate
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Synonyms:
Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-,acetate (ester),(3β)-;CB 7630;Abiraterone acetate;Zytiga;(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate;1643848-36-5
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CAS No:
Description
Off-White SolidChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance.In April 2011, the United States FDA approved abiraterone acetate(CB7630) in combination with the steroid prednisone for the treatmentof metastatic castration-resistant prostate cancer (mCRPC) for patientswho were previously
Characteristics
39.2
6.55
1.14±0.1 g/cm3(Predicted)
144-145 °C @ Solvent: Hexane
506.7±50.0 °C(Predicted)
260.2±30.1 °C
1.584
-20°C Freezer
2.17E-10mmHg at 25°C
Abiraterone acetate Use and Manufacturing
Scientific research reagents are widely used in molecular biology, pharmacology and other scientific research. Abiraterone acetate is converted into abiraterone in the body, an androgen biosynthesis inhibitor that inhibits 17α-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in testis, adrenal glands, and prostate tumor tissues and is required for androgen biosynthesis.
Drug Function and Efficacy
Inhibits androgen synthesis
Registered Holders
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CDYMAX (INDIA) PHARMA PRIVATE LTD
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United States
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SHILPA PHARMA LIFESCIENCES LTD
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United States
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RAKS PHARMA PVT LTD
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United States
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