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Decoquinate

Decoquinate structure

CAS No:
18507-89-6
Formula:
C24H35NO5
Chemical Name:
Decoquinate
Synonyms:
3-Quinolinecarboxylic acid,6-(decyloxy)-7-ethoxy-4-hydroxy-,ethyl ester;Ethyl 6-n-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate;Deccox;Decoquinate;M and B 15497;Ethyl 6-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate;Ethyl 4-hydroxy-6-(decyloxy)-7-ethoxyquinoline-3-carboxylate;Decoxy;HC 1528;NSC 339057;55352-59-5
Categories:
Active Pharmaceutical Ingredients > Veterinary Raw Materials

Description

Off-White to Pale Yellow SolidDecoquinate is a new type highly-efficienct quinolones anti-coccidiosis for livestock and poultry, commonly known as quinoxetine, decanoquinolate, paclitaxel, to quinolate, benzoquinone. The active compound is white or slightly yellow crystalline powder, rarely soluble in chloroform or ether, insoluble in water or ethanol. It has a unique anti-coccidial activity stronger than Maduramicin, nicarbazine + Ethanamidobenzylate, methyl salicin. Studies have shown that de

Decoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites.|A coccidiostat for poultry.

Decoquinate Basic Attributes

Molecular Weight：

417.5384

Exact Mass：

417.54

EC Number：

242-389-1

UNII：

534I52PVWH

NSC Number：

759109|339057

DSSTox ID：

DTXSID5046851

HScode：

29334900

Characteristics

PSA：

73.9

XLogP3：

6.8

Appearance：

pale yellow crystals

Density：

1.091±0.06 g/cm3(Predicted)

Melting Point：

242-245 °C

Boiling Point：

517.9±45.0 °C(Predicted)

Flash Point：

267.0±28.7 °C

Refractive Index：

1.541

Water Solubility：

Slightly soluble in chloroform, ether, almost insoluble in water.

Vapor Pressure：

1.25E-11mmHg at 25°C

Toxicity：

Decoquinate is well tolerated with low toxicity and dosage 80 times of the recommended is still safe.
Poultry: addition of 800ppm in fodder (26 times the normal dosage) with continuous feeding for 127 days caused no poisoning;
Pigs: 800ppm continuous feeding for 10 days caused no poisoning.

Collision Cross Section：

216.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

VB1983800

Precautionary statement(s)：

P273, P501

Hazard Statements：

H413

GHS Classification：

H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|Aggregated GHS information provided by 195 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)

MeSH Entry Terms：

Deccox

Decoquinate Use and Manufacturing

Methods of Manufacturing

3, 4-dihydroxynitrobenzene reacts with bromodecane in DMF medium to produce 3-hydroxy-4-decoxynitrobenzene. Then, through ethoxylation and reduction, 3-ethoxy-4-decoxyaniline is prepared. Then, 3-ethoxy-4-decoxyaniline is condensed with diethyl ethoxymethylenemalonate to give 3-ethoxy-4-decoxyanilinylmethylenemalonate diethyl The ester is finally heated and condensed by thermal conductivity A to obtain the finished product.

Uses

antiviral Quinoline coccidia medicine. As a feed additive to prevent broiler coccidiosis, add 27.2g of this product to 1t feed. The product has low toxicity, good tolerance and wide safety range. Metabolism is rapid. After 3 days of drug withdrawal, the concentration of residual drug in each tissue is less than 1 ppm. Antiprotozoal medicine for chicken coccidiosis.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:417.5
XLogP3:6.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:15
Exact Mass:417.25152322
Monoisotopic Mass:417.25152322
Topological Polar Surface Area:73.9
Heavy Atom Count:30
Complexity:562
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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