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Ciclopirox olamine

Ciclopirox olamine structure

CAS No:
41621-49-2
Formula:
C12H17NO2.C2H7NO
Chemical Name:
Ciclopirox olamine
Synonyms:
2(1H)-Pyridinone,6-cyclohexyl-1-hydroxy-4-methyl-,compd. with 2-aminoethanol (1:1);Ethanol,2-amino-,compd. with 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone (1:1);HOE 296;1-Hydroxy-4-methyl-6-cyclohexyl-2-pyridinone ethanolamine salt;Ciclopirox olamine;Batrafen;Loprox;Mycoster;Brumixol;Micoxolamina;Terit;Ciclochem;NSC 336278;Ciclopirox ethanolamine (1:1);Sebiprox;Fungowas;Selergo
Categories:
Cosmetic Ingredient > Anti-seborrheic

Description

Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor.

Ciclopirox Olamine is the olamine salt form of ciclopirox, a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).|A cyclohexane and pyridinone derivative that is used for the treatment of fungal infections of the skin and nails, and for treatment of VAGINAL YEAST INFECTIONS.

Ciclopirox olamine Basic Attributes

Molecular Weight：

268.35

Exact Mass：

268.178680

EC Number：

255-464-9

UNII：

50MD4SB4AP

NSC Number：

756694|336278

DSSTox ID：

DTXSID6045583

NCI Thesaurus Code：

C65327

HScode：

2933790002

Characteristics

PSA：

86.8

XLogP3：

2.07940

Appearance：

White or pale yellow crystalline powder

Melting Point：

144 C

Boiling Point：

350°C at 760 mmHg

Flash Point：

165.5ºC

Toxicity：

Oral-rat LD50: 2350 mg/kg; Oral-Mouse LD50; 1740 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-42/43-20/22

safety instructions：

26-36-22

RTECS Number：

UU7785500

Marks：

Xi,Xn

Storage features：

Ventilated, low temperature and dry

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (44.44%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 109 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt

Ciclopirox olamine Use and Manufacturing

Methods of Manufacturing

The HBTA-4 1- hydroxy-4-methyl-6-cyclohexyl -2 (1H) - pyridone was dissolved in 35ml of ethyl acetate, then 2-aminoethanol was added, and vigorous stirring at 50 deg.] C to precipitate quickly crystals, stirring was continued for 30min, cooled to room temperature, filtered off with suction, washed with ethyl acetate, and dried 45 deg.] C, as a white powdery product ciclopirox.

Uses

Ciclopirox (C432800) derivative. Broad spectrum antimycotic agent with some antibacterial activity.

Use Classification：

Cosmetics -> Antidandruff; Antimicrobial

Computed Properties

Molecular Weight:268.35
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:268.17869263
Monoisotopic Mass:268.17869263
Topological Polar Surface Area:86.8
Heavy Atom Count:19
Complexity:335
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ciclopirox olamine vaginal suppository
Ingredients	Ciclopirox olamine.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.1g
Manufacturer	Mayinglong Pharmaceutical Group Co., Ltd.

Ciclopirox olamine cream
Ingredients	Each gram of this product contains 10 mg of the main ingredient, ciclopirox olamine. The excipients are octadecyl alcohol, stearic acid, white vaseline, Span-60, dimethicone, propylene glycol, glycerin, Tween-80, benzoic acid, menthol, S-40, isopropyl palmitate, lactic acid, medicinal ethanol, and water.
Indication	If you are using other medicines, please consult your physician or pharmacist before use.
Specifications	10g:01g
Manufacturer	Anhui Shengying Pharmaceutical Co., Ltd.

Ciclopirox olamine cream
Ingredients	Each gram of this product contains 10 mg of the main ingredient, ciclopirox olamine. The excipients are octadecyl alcohol, stearic acid, white vaseline, Span-60, dimethicone, propylene glycol, glycerin, Tween-80, benzoic acid, menthol, S-40, isopropyl palmitate, lactic acid, medicinal ethanol, and water.
Indication	If you are using other medicines, please consult your physician or pharmacist before use.
Specifications	10g:0.1g
Manufacturer	Hubei KEYI Pharmaceutical Industry Co., Ltd.

See More Related Drugs

Registered Holders

KUMAR ORGANIC PRODUCTS LIMITED

United Kingdom
Active
OLON S.P.A.

Italy
Active
Xuchang Future Pharmaceutical Co., Ltd.

China
Active

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Provide Top Quality Ciclopirox Olamine CAS 41621-49-2

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CICLOPIROX OLAMINE

CAS No.: 41621-49-2

Grade: Pharmaceutical Grade

Content: 99%

Inquiry

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Guide of Ciclopirox olamine

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

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