FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
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FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
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CAS No:
106096-93-9
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Formula:
NULL
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Chemical Name:
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
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Synonyms:
RHBFGF;RHFGFB;RECOMBINANT HUMAN FGF-BASIC;REC FIBROBLAST GROWTH FACTOR BASIC (HUMAN);kcb-1;recombinanthumanbasicfibroblastgrowthfactor,kcb-1;Fibroblast Growth Factor, Basic, Human, Recomb.;Fibroblast growth factlr
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CAS No:
Description
Fibroblast growth factor-basic (FGF-Basic) is found in basement membranes and sub-endothelial extracellular matrix. FGF-Basic is induced early in the development of the embryo where it is necessary (but not sufficient) for pluripotency and self-renewal of embryonic stem cells (ESC) and lineage defined stem cells; wherein it functions to support proliferation and inhibit differentiation. Self-renewal of hESC depends upon activation of the Activin/Nodal/Smad2,3 branch and suppression of the BMP/GDF/Smad5 branch of the TGFβ-family cell signaling program. FGF-Basic is a competence factor for Nodal support of pluripotency. Activin-A is necessary and sufficient to maintain stemness. It induces the expression of both Nodal and FGF-Basic in human ES cells.
Fibroblast Growth Factor-2 Human Recombinant (FGF-2) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 154 amino acids and having a molecular mass of 17.2kDa.The FGF-b is purified by proprietary chromatographic techniques.
Escherichia Coli
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN Use and Manufacturing
Fibroblast growth factor-basic (FGF-Basic) is required for the maintenance of human embryonic stem cells in culture, and various other stem cell lines, such as mesenchymal stem (stroma) cells (MSC).
Drug Function and Efficacy
This product is a multifunctional cell growth factor that can stimulate the proliferation of cells derived from mesoderm and neuroectoderm, induce inflammatory cells, fibroblasts, vascular endothelial cells, etc. to move to the injured site, activate the phagocytic function of macrophages, improve the body's immune function, reduce the chance of wound infection, and promote the proliferation of fibroblasts, promote the formation of new capillaries, promote epithelial cell proliferation and sensory function, while inhibiting the expression of gelatinase, preventing the formation of pathological scars, and promoting repair and regeneration.
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