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Azithromycin dihydrate

Azithromycin dihydrate structure

CAS No:
117772-70-0
Formula:
C38H72N2O12.2H2O
Chemical Name:
Azithromycin dihydrate
Synonyms:
1-Oxa-6-azacyclopentadecan-15-one,13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-,dihydrate,(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-;1-Oxa-6-azacyclopentadecan-15-one,13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-,dihydrate,[2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-;Azithromycin dihydrate;Zithrokan;Azrolid
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

Azithromycin is a semisynthetic macrolide antibiotic which is commonly used for a wide variety of mild-to-moderate bacterial infections. Azithromycin has been linked to rare instances of acute liver injury.

Azithromycin dihydrate Basic Attributes

Molecular Weight：

748.99

Exact Mass：

784.529663

EC Number：

1592732-453-0

HScode：

29419000

Characteristics

PSA：

182

XLogP3：

1.71000

Appearance：

off-white

Density：

1.18g/cm3

Melting Point：

126 C

Boiling Point：

717℃

Flash Point：

>110°(230°F)

Water Solubility：

soluble in DMSO at 20mg/ml. Also soluble in chloroform or ethylene chloride

Storage Conditions：

-20°C Freezer

Vapor Pressure：

2.51E-31mmHg at 25°C

Specific rotation：

D26 -41.4° (c = 1 in CHCl3)

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

36/37/38

safety instructions：

24/25-36/37/39

RTECS Number：

RN6960000

Marks：

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 41 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Hepatotoxicity：

Like other macrolide antibiotics, azithromycin has been linked to a low rate of acute, transient and asymptomatic elevation in serum aminotransferases which occurs in 1% to 2% of patients treated for short periods, and a somewhat higher proportion of patients given azithromycin long term.

Drug Information

LiverTox Summary：

Drug Classes：

Antiinfective Agents

Azithromycin dihydrate Use and Manufacturing

Semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.

Computed Properties

Molecular Weight:785.0
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:7
Exact Mass:784.52965510
Monoisotopic Mass:784.52965510
Topological Polar Surface Area:182
Heavy Atom Count:54
Complexity:1150
Defined Atom Stereocenter Count:17
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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