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Closantel

Closantel structure

CAS No:
57808-65-8
Formula:
C22H14Cl2I2N2O2
Chemical Name:
Closantel
Synonyms:
Benzamide,N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-;N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide;Closantel;NSC 335306;Zycloz;Seponver;Clozantin;S 4105
Categories:
Analytical Chemistry > Standard

Description

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Closantel Basic Attributes

Molecular Weight：

663.07

Exact Mass：

663.07

EC Number：

260-967-1

NSC Number：

759819|335306

DSSTox ID：

DTXSID6040662

Characteristics

PSA：

73.1

XLogP3：

7.2

Density：

1.9±0.1 g/cm3

Melting Point：

217.8 °C

Boiling Point：

590.5°C at 760 mmHg

Flash Point：

310.9±30.1 °C

Refractive Index：

1.736

Storage Conditions：

0-6°C

Toxicity：

Oral-rat LD50: 262 mg/kg; Oral-Mouse LD50: 331 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxides, chlorides, iodide fumes

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

2811

wgk germany：

hazard class code：

RTECS Number：

CV2444250

Marks：

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301-H413

GHS Classification：

|Danger|H301 (97.71%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 131 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)|Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)

MeSH Entry Terms：

closantel

Closantel Use and Manufacturing

Uses

antianginal, antihypertensive

Use Classification：

Veterinary Drug -> ANTHELMINTHIC_AGENT; -> JECFA Functional Classes

Food Additive Classes：

Veterinary Drug -> ANTHELMINTHIC_AGENT;

Computed Properties

Molecular Weight:663.1
XLogP3:7.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:661.85218
Monoisotopic Mass:661.85218
Topological Polar Surface Area:73.1
Heavy Atom Count:30
Complexity:652
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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