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(±)-Trimebutine

(±)-Trimebutine structure

CAS No:
39133-31-8
Formula:
C22H29NO5
Chemical Name:
(±)-Trimebutine
Synonyms:
Benzoic acid,3,4,5-trimethoxy-,2-(dimethylamino)-2-phenylbutyl ester;Trimebutine;(±)-Trimebutine;Triton;Triton (pharmaceutical);[2-(Dimethylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate;2-(Dimethylamino)-2-phenylbutyl (-)-3,4,5-trimethoxybenzoate;58997-88-9
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a prematu

(±)-Trimebutine Basic Attributes

Molecular Weight：

387.47

Exact Mass：

387.47

EC Number：

254-309-2

HScode：

2922199090

Characteristics

PSA：

57.2

XLogP3：

Density：

1.1±0.1 g/cm3

Melting Point：

79 °C

Flash Point：

230.8±25.7 °C

Refractive Index：

1.534

Water Solubility：

H2O: Insoluble

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

(±)-Trimebutine Use and Manufacturing

Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.

Drug Function and Efficacy

Effect on digestive tract motility: It regulates gastric motility and can make irregular gastric motility regular; it is inhibited when the motility of the gastric pylorus is hyperactive, and its activity is enhanced when the motility is hypoactive. It has an inducing effect on the propulsion of the digestive system, and has an excitatory effect on gastric emptying disorders caused by chronic gastritis, which improves gastric emptying. At the same time, it has an inhibitory effect on hyperactive gastric emptying. It has a direct effect on the smooth muscle of the digestive tract. It can still directly act on the smooth muscle after the application of atropine, phentolamine, propranolol and puffer fish toxin. It can produce a non-competitive inhibitory effect on the effect of acetylcholine on the isolated ileum of guinea pigs. It has a peripheral antiemetic effect. For vomiting induced by copper sulfate, it can significantly prolong the time required to induce vomiting after intravenous injection or oral administration.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Trimebutine Maleate Capsules
Ingredients	Main ingredients: trimebutine. 3,4,5-trimethoxybenzoic acid-2-dimethylamino-2-phenylbutyl ester maleate
Indication	Missing information.
Specifications	0.1g (calculated according to C22H29NO5·C4H4O4)
Manufacturer	Shanxi Zhendong Anxin Biopharmaceutical Co., Ltd.

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