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Prasugrel hydrochloride

Prasugrel hydrochloride structure

CAS No:
389574-19-0
Formula:
C20H20FNO3S.ClH
Chemical Name:
Prasugrel hydrochloride
Synonyms:
Ethanone,2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-,hydrochloride (1:1);Ethanone,2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-,hydrochloride;Prasugrel hydrochloride;2-Acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride;Prasu Doc;Efient;Effient
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 μM.Target: P2Y12 receptorPrasugrel hydrochloride is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI [2].Prasugrel hydrochloride reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel hydrochloride AM inhibited in vi

A piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those undergoing PERCUTANEOUS CORONARY INTERVENTIONS.

Prasugrel hydrochloride Basic Attributes

Molecular Weight：

409.9

Exact Mass：

409.091461

DSSTox ID：

DTXSID1049067

HScode：

2934990002

Characteristics

PSA：

74.8

XLogP3：

4.63090

Appearance：

White to off-white solid

Boiling Point：

493.5°C at 760 mmHg

Safety Information

Precautionary statement(s)：

P260, P264, P270, P273, P280, P301+P312, P305+P351+P338, P314, P330, P337+P313, P391, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P305+P351+P338, P314, P330, P337+P313, P391, and P501|Aggregated GHS information provided by 5 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Prevention of thromboembolic events

MeSH：

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

MeSH Entry Terms：

640315, LY

Prasugrel hydrochloride Use and Manufacturing

Uses

A novel antiplatelet agent; it is a third-generation thienopyridine. y induce increased incidence of bleeding in patient with acute coronary syndrome

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:409.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:409.0914706
Monoisotopic Mass:409.0914706
Topological Polar Surface Area:74.8
Heavy Atom Count:27
Complexity:555
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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