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Ceftezole sodium

Ceftezole sodium structure

CAS No:
41136-22-5
Formula:
C13H12N8O4S3.Na
Chemical Name:
Ceftezole sodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-,sodium salt (1:1),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-,monosodium salt,(6R-trans)-;Sodium 7-[(1H-tetrazol-4-yl)acetyl]-3-(1,3,4-thiadiazol-5-ylthio)cephalosporanate;Ceftezole sodium;Celoslin;81078-06-0
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity[1][2].

Ceftezole Sodium is a N-acyl-amino acid.|Ceftezole Sodium is the sodium salt form of ceftezole, a semi-synthetic first-generation cephalosporin with antibacterial activity.

Ceftezole sodium Basic Attributes

Molecular Weight：

462.46

Exact Mass：

461.996307

EC Number：

1592732-453-0

UNII：

3NHZ4Y117H

DSSTox ID：

DTXSID1048594

NCI Thesaurus Code：

C98231

Characteristics

PSA：

238

XLogP3：

-1.95040

Density：

2.09 g/cm3

Toxicity：

Intravenous-rat LD50: 3800 mg/kg; Intravenous-mouse LD50: 4700 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, sodium oxide fumes

Safety Information

Storage features：

The warehouse is low-temperature, ventilated and dry

Toxicity

Toxicity class：

practically nontoxic

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

ceftezol

Computed Properties

Molecular Weight:462.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:7
Exact Mass:461.99630866
Monoisotopic Mass:461.99630866
Topological Polar Surface Area:238
Heavy Atom Count:29
Complexity:716
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It exerts antibacterial activity by inhibiting the synthesis of bacterial cell walls. It has antibacterial activity against aerobic Gram-positive bacteria (such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes) and aerobic Gram-negative bacteria (such as Escherichia coli, Klebsiella pneumoniae, Proteus).

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefotezol Sodium for Injection
Ingredients	This product is a sterile powder of ceftezole sodium. Its chemical name is: sodium (6R, 7R)-3-[(1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetylamino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.
Indication	Not yet clear.
Specifications	2.0g (calculated as C13H12N8O4S3: 2.0g)
Manufacturer	Guangxi Kelun Pharmaceutical Co., Ltd.

Cefotezole Sodium

Cefotezol Sodium for Injection
Ingredients	This product is a sterile powder of ceftezole sodium. Its chemical name is: sodium (6R, 7R)-3-[(1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetylamino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.
Indication	Not yet clear.
Specifications	0.5g (calculated as C13H12N8O4S3)
Manufacturer	Hainan Guangshengyu Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

China
Active
Shandong Ruiying Pioneer Pharmaceutical Co., Ltd.

China
Active
Hainan Huluwa Pharmaceutical Group Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Ceftezole sodium

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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ceftezole sodium 41136-22-5

CAS No.: 41136-22-5

Grade: Pharmaceutical Grade

Content: 99%

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