3,5-Dichlorophenol Safety Data Sheets

Acute toxicity - Category 4, Oral

Acute toxicity - Category 3, Dermal

Skin corrosion, Sub-category 1B

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes and upper respiratory tract. Prolonged contact can cause damage to the eyes, severe irritation and burns. Exposure to this class of compounds may cause profuse sweating, intense thirst, abdominal pain, nausea, vomiting, diarrhea, cyanosis from methemoglobinemia, hyperactivity, stupor, blood pressure fall, hyperpnea, hemolysis, convulsions, collapse, coma and pulmonary edema followed by pneumonia. If death from respiratory failure is not immediate, jaundice and oliguria or anuria may occur. Other symptoms of exposure to this class of compounds may include headache, dizziness, rapid and difficult breathing, weakness, severe burns and internal damage. Chronic exposure may result in digestive disturbances, nervous disorders, skin eruptions and liver and kidney damage. Skin contact with this type of compound may result in softening and whitening of the skin, followed by the development of painful burns. Prolonged contact may lead to dermatitis. Local contact may also result in painless blanching or erythema and corrosion of the skin. Skin sensitivity reactions occur occasionally. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It is an irritant of the skin, eyes, mucous membranes and upper respiratory tract; and prolonged contact may result in severe irritation or burns. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and hydrogen chloride gas. (NTP, 1992)

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

Use water spray, foam, powder, carbon dioxide.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Land Spill: Dig a pit, pond, lagoon, or holding area /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./to contain liquid or solid material. Cover solids with plastic sheet to prevent dissolving in rain or fire fighting water. Trichlorophenol

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store only in original container. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Separated from oxidants and food and feedstuffs. Ventilation along the floor.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on heating. This produces toxic and corrosive fumes including acid anhydrides and hydrogen chloride. Decomposes on burning. This produces toxic fumes including phosgene. Reacts with strong oxidants.

no data available

3,5-DICHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. (NTP, 1992)

no data available

no data available

When heated to decomposition it emits toxic vapors of /hydrogen chloride/.

Acute toxicity

• Oral: LD50 Mouse (male CD-1 ICR) oral 2643 mg/kg.
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: Danio rerio (Zebra danio, length 2.5 cm); Conditions: freshwater, static, 22 deg C, pH 7.8-8, hardness 150 mg/L CaCO3; Concentration: 1000-3500 ug/L for 24 hr
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae, age 3 days, exponential growth phase); Conditions: freshwater, static, 23 deg C, flask bioassay, continuous white light and stirring; Concentration: 1790 ug/L for 72 hr (95% confidence interval: 1660-1920 ug/L); Effect: decreased population growth rate /100% purity
• Toxicity to microorganisms: no data available

Bacterial toxicity limits determined by 5 methods agreed with limits found in degradation tests in lab activated sludge equipment. in biodegradation tests with industrial wastewater, bacteria became adapted to 3,5-dichlorophenol within a few weeks.

A BCF range of 9 to 82 was measured in fish for 3,5-dichlorophenol using carp (Cyprinus carpio) which were exposed over a eight week period to a water concentration of 30 ppb, according to the standard test of the Japanese Ministry of Industry and Trade (MITI)(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

The Koc of 3,5-dichlorophenol is estimated as 1,200(SRC), using a log Kow of 3.62(1), and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 3,5-dichlorophenol is expected to have low mobility in soil. The pKa of 3,5-dichlorophenol is 8.18(4), indicating that this compound will partially exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.The substance is combustible but no flash point is available in literature.See ICSCs 0438 and 0439.