L-Aspartic acid Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | Aspartic acid |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | L-Asparticacid; asparagic acid; 1-amino-1,2-carboxyethane |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Food additives -> Flavoring Agents |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
|---|---|
| Signal word | No signal word |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Aspartic acid | Aspartic acid | 56-84-8 | 200-291-6 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink.
4.2 Most important symptoms/effects, acute and delayed
no data available
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool . Cover skin burns with dry sterile dressings after decontamination . Poisons A and B
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
In case of fire in the surroundings, use appropriate extinguishing media.
5.2 Specific hazards arising from the chemical
Combustible. Finely dispersed particles form explosive mixtures in air.
5.3 Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
6.2 Environmental precautions
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
6.3 Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Prevent build-up of electrostatic charges (e.g., by grounding). Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
| Component | Aspartic acid | |||
|---|---|---|---|---|
| CAS No. | 56-84-8 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Latvia | Â | 10 | Â | Â |
| Remarks | ||||
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety spectacles.
Skin protection
Protective gloves.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Solid. |
|---|---|
| Colour | White. |
| Odour | no data available |
| Melting point/freezing point | 230 °C. |
| Boiling point or initial boiling point and boiling range | > 324 °C. |
| Flammability | Combustible. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 107°C(lit.) |
| Auto-ignition temperature | > 400 °C. |
| Decomposition temperature | 324°C |
| pH | 3.03. Remarks:Suspension at ambient temperature. |
| Kinematic viscosity | no data available |
| Solubility | In water: 2.09 g/kg. Temperature:0 °C. Remarks:Selected results from the solubility-temperature equation.;3.53 g/kg. Temperature:15 °C. Remarks:Selected results from the solubility-temperature equation.;4.2 g/kg. Temperature:20 °C. Remarks:Selected results from the solubility-temperature equation. |
| Partition coefficient n-octanol/water | log Pow = -3.89. Remarks:No further data are available. |
| Vapour pressure | 0 Pa. Temperature:25 °C. Remarks:The result was obtained by the Modified Grain method. |
| Density and/or relative density | 1.66. Temperature:13 °C.;1.661. Temperature:13 °C. |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on burning. This produces toxic gases including nitrogen oxides. Reacts violently with oxidants.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
no data available
10.6 Hazardous decomposition products
no data available
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - 2 000 mg/kg bw.
- Inhalation: no data available
- Dermal: LD50 - rabbit - 5 000 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes and respiratory tract.
STOT-repeated exposure
no data available
Aspiration hazard
Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - > 100 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 100 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - > 100 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge of a predominantly domestic sewage - > 300 mg/L - 3 h. Remarks:Respiration rate.
12.2 Persistence and degradability
AEROBIC: The biodegradation of L-aspartic acid was measured in several BOD5 tests. After 5 days, 48.5%(1) 38.7(2) and 80.5%(3) of the theoretical BOD was reached using a sewage inoculum. L-Aspartic acid was degraded by 81% BODT after 30 days using a sewage inoculum(4). In a second Warburg test using an activated sludge inoculum, 8.9, 16.2, and 28.8% BODT was reached after 0.25, 0.5, and 1 day, respectively(5). DL-Aspartic acid was rapidly degraded by 98 to >99% in a laboratory-scale activated sludge unit at initial concentrations of 599, 1198, 2396, and 4792 mg/L and average detention times of 20.5, 29, 42, and 85 hours, respectively(6). Samples of marine water from the Scheldt estuary, the Belgian coastal zone of the North Sea, and the English Channel were incubated with 14C-labeled DL-aspartic acid and relative rates of total utilization (incorporation plus respiration) of 2.7, 1.5, and 0.10%/hr, respectively, were measured over a 4-hour period(7). Based on these data, L-aspartic acid is expected to biodegrade rapidly.
12.3 Bioaccumulative potential
An estimated BCF of 0.7 was calculated in fish for L-aspartic acid(SRC), using a water solubility of 5,360 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of L-aspartic acid is estimated as 39(SRC), using a water solubility of 5,360 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that L-aspartic acid is expected to have very high mobility in soil. However, L-aspartic acid has pKa values of 1.92, 3.87, and 9.87(5), indicating that this compound will exist as a zwitterion in the environment. In H(Al) montmorillonite, aspartic acid showed an L-2 type adsorption isotherm with an initial preferential sorption when compared with the solvent or other solutes followed by a decrease in sorption as more solute was sorbed(4).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Aspartic acid | Aspartic acid | 56-84-8 | 200-291-6 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
L-Aspartic acid is included in Antistatic category.
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