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5-MAPB dose-dependently causes long-lasting 5-HT depletions in rats
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Albert Pyzik
5-MAPB dose-dependently causes long-lasting 5-HT depletions in rats
Also, I have been quite critical, but I only disagree with the comparison you made to MDMA. Any additional information we get on these compounds helps out a lot, keep up the good work, and thank you for the study.
Also, I have been quite critical, but I only disagree with the comparison you made to MDMA. Any additional information we get on these compounds helps out a lot, keep up the good work, and thank you for the study.More
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What does similat serotonin depletion have to do with the supposed toxicity of differing metabolites? I think neurotoxicity is a difficult thing to ascertain from partial evidence.
What does similat serotonin depletion have to do with the supposed toxicity of differing metabolites? I think neurotoxicity is a difficult thing to ascertain from partial evidence.More
There is a theory that so-called MDMA neurotoxicity, which has been measured as long-lasting 5-HT depletions, is caused by specific MDMA metabolites. This led some to speculate that 5-MAPB, which would not form the same metabolites, would not have similar toxicity. That seems incorrect, although the data are of course incomplete.More
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Have you studied 5-apb and 5-mapb for 5ht-2b agonism and potential heart damage? 6-apb is certainly awful in this regard.
We did a quick and dirty screening which suggested 5-MAPB doesn't effectively stimulate 5-HT2B. Didn't look at 5-APB but it was found to be a potent 5-HT2B agonist by Iverson et al https://doi.org/10.1016/j.ejphar.2012.12.006More
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5-MAPB was supposed to not form metabolites that block replenishment of the serotonin afterwards, like it is the case with MDMA metabolites.
Very insightful research. Can't wait to see the published paper. Thanks for your work!More
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2 weeks? Thats surely not long enough if you are talking about actual permanent neurotoxic damage as opposed to just depleted stores of serotonin, big difference between depleted stords that build back up and damaged axons that remain dysfunctional.
2 weeks? Thats surely not long enough if you are talking about actual permanent neurotoxic damage as opposed to just depleted stores of serotonin, big difference between depleted stords that build back up and damaged axons that remain dysfunctional.More
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