Home > Community > Anyone ever ran an amide coupling reaction using the TFA salt of the amine?
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KEVIN WILCOX

Anyone ever ran an amide coupling reaction using the TFA salt of the amine?

I deprotected my amine using TFA and rotovapped the solvent and excess TFA off. Now I’m going to use EDC and HOBT to form an amide. I was wondering if it’s possible to leave the amine as the TFA salt, and add some DIPEA in the reaction to deprotonate in situ. Anyone have any experience with this? Will I get some coupling with TFA if I do this?

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