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Cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA): Solubility in ethanol
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Posted by
M Schoenberger
Cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA): Solubility in ethanol
I did a bit of research but could not find any source on solubility of these substances in ethanol.
ChemSpider has some indirect prediction of the solubility of CBGA and GBDA in the form of a logP value. In a two phase system of water and octanol, substances with higher logP have a higher fraction in the octanol phase. Ethanol has a logP of −0.18, while the two compounds of interest have predicted values of about 7. This suggests ethanol would not be the best solvent, and water would be even worse. Something like Vitamin E acetate (infamous for vaping lung injuries) might be a better solvent.
The ChemSpider site also has information about toxicity, which typically increases with concentration or purity.
For context, I'm looking to extract these from two different strains of ground cannabis flowers, one of which has a high concentration of CBGA and the other a high concentration of CBDA.
The flowers probably have a pH near neutral (like other plant tissue). At neutral pH, both CBDA and CBGA would be deprotonated, making ethanol a poor solvent and water a good one.
I did a bit of research but could not find any source on solubility of these substances in ethanol.
ChemSpider has some indirect prediction of the solubility of CBGA and GBDA in the form of a logP value. In a two phase system of water and octanol, substances with higher logP have a higher fraction in the octanol phase. Ethanol has a logP of −0.18, while the two compounds of interest have predicted values of about 7. This suggests ethanol would not be the best solvent, and water would be even worse. Something like Vitamin E acetate (infamous for vaping lung injuries) might be a better solvent.
The ChemSpider site also has information about toxicity, which typically increases with concentration or purity.
For context, I'm looking to extract these from two different strains of ground cannabis flowers, one of which has a high concentration of CBGA and the other a high concentration of CBDA.
The flowers probably have a pH near neutral (like other plant tissue). At neutral pH, both CBDA and CBGA would be deprotonated, making ethanol a poor solvent and water a good one.
ChemSpider has some indirect prediction of the solubility of CBGA and GBDA in the form of a logP value. In a two phase system of water and octanol, substances with higher logP have a higher fraction in the octanol phase. Ethanol has a logP of −0.18, while the two compounds of interest have predicted values of about 7. This suggests ethanol would not be the best solvent, and water would be even worse. Something like Vitamin E acetate (infamous for vaping lung injuries) might be a better solvent.
The ChemSpider site also has information about toxicity, which typically increases with concentration or purity.
The flowers probably have a pH near neutral (like other plant tissue). At neutral pH, both CBDA and CBGA would be deprotonated, making ethanol a poor solvent and water a good one.
ChemSpider has some indirect prediction of the solubility of CBGA and GBDA in the form of a logP value. In a two phase system of water and octanol, substances with higher logP have a higher fraction in the octanol phase. Ethanol has a logP of −0.18, while the two compounds of interest have predicted values of about 7. This suggests ethanol would not be the best solvent, and water would be even worse. Something like Vitamin E acetate (infamous for vaping lung injuries) might be a better solvent.
The ChemSpider site also has information about toxicity, which typically increases with concentration or purity.
The flowers probably have a pH near neutral (like other plant tissue). At neutral pH, both CBDA and CBGA would be deprotonated, making ethanol a poor solvent and water a good one.
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