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Could anybody tell about synthesis of 3,5 dimethylpyrazole?
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Marinel Subu
Could anybody tell about synthesis of 3,5 dimethylpyrazole?
You can synthesize 3,5-dimethylpyrazole from acetyl acetone. You will also need Hydrazine hydrate and Ethanol for the reaction. The reaction will go on in this way. 1. Take 6ml of hydrazine hydrate in a 250ml flask. To this add around 50ml of ethanol with constant stirring. 2.Now place the flask in ice bath for 10 minutes. 3. Add slowly 10ml of acetyl acetone drop wise to the above solution at low temperature with constant stirring. Take around 20 minutes or more to add acetyl acetone. 4. Allow the reaction mixture to come to the room temperature and then reflux for an hour in oil bath with temperature around 110 degree celsius. Then remove the solvent to dryness on rotavapor and add few mL of n-hexane to dissolve the solid in lukewarm condition. Place the flask in refrigerator to get crystalline solid. Collect the solid product by filtration. You may use cold hexane to wash the product.
You can synthesize 3,5-dimethylpyrazole from acetyl acetone. You will also need Hydrazine hydrate and Ethanol for the reaction. The reaction will go on in this way. 1. Take 6ml of hydrazine hydrate in a 250ml flask. To this add around 50ml of ethanol with constant stirring. 2.Now place the flask in ice bath for 10 minutes. 3. Add slowly 10ml of acetyl acetone drop wise to the above solution at low temperature with constant stirring. Take around 20 minutes or more to add acetyl acetone. 4. Allow the reaction mixture to come to the room temperature and then reflux for an hour in oil bath with temperature around 110 degree celsius. Then remove the solvent to dryness on rotavapor and add few mL of n-hexane to dissolve the solid in lukewarm condition. Place the flask in refrigerator to get crystalline solid. Collect the solid product by filtration. You may use cold hexane to wash the product.
One can react appropriately N - alkyl/aryl hydrazines with acetylacetone ( like Methylhydrazine, phenylhydrazines etc.) to get N-alkyl/aryl-3,5-dimethylpyrazoles. Suggestion is similar to Hendrik and Manuri
One can react appropriately N - alkyl/aryl hydrazines with acetylacetone ( like Methylhydrazine, phenylhydrazines etc.) to get N-alkyl/aryl-3,5-dimethylpyrazoles. Suggestion is similar to Hendrik and Manuri
Guareschi reaction can be used for the preparation of this compound. In this reaction ethyl cyanoacetate with ketone and ammonia react or in another way react 2-cyanoacrylates with cyanoacetamide.
Guareschi reaction can be used for the preparation of this compound. In this reaction ethyl cyanoacetate with ketone and ammonia react or in another way react 2-cyanoacrylates with cyanoacetamide.
You can synthesize 3,5-dimethylpyrazole from acetyl acetone. You will also need Hydrazine hydrate and Ethanol for the reaction. The reaction will go on in this way.
1. Take 6ml of hydrazine hydrate in a 250ml flask. To this add around 50ml of ethanol with constant stirring.
2.Now place the flask in ice bath for 10 minutes.
3. Add slowly 10ml of acetyl acetone drop wise to the above solution at low temperature with constant stirring. Take around 20 minutes or more to add acetyl acetone.
4. Allow the reaction mixture to come to the room temperature and then reflux for an hour in oil bath with temperature around 110 degree celsius. Then remove the solvent to dryness on rotavapor and add few mL of n-hexane to dissolve the solid in lukewarm condition. Place the flask in refrigerator to get crystalline solid. Collect the solid product by filtration. You may use cold hexane to wash the product.
You can synthesize 3,5-dimethylpyrazole from acetyl acetone. You will also need Hydrazine hydrate and Ethanol for the reaction. The reaction will go on in this way.
1. Take 6ml of hydrazine hydrate in a 250ml flask. To this add around 50ml of ethanol with constant stirring.
2.Now place the flask in ice bath for 10 minutes.
3. Add slowly 10ml of acetyl acetone drop wise to the above solution at low temperature with constant stirring. Take around 20 minutes or more to add acetyl acetone.
4. Allow the reaction mixture to come to the room temperature and then reflux for an hour in oil bath with temperature around 110 degree celsius. Then remove the solvent to dryness on rotavapor and add few mL of n-hexane to dissolve the solid in lukewarm condition. Place the flask in refrigerator to get crystalline solid. Collect the solid product by filtration. You may use cold hexane to wash the product.
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One can react appropriately N - alkyl/aryl hydrazines with acetylacetone ( like Methylhydrazine, phenylhydrazines etc.) to get N-alkyl/aryl-3,5-dimethylpyrazoles. Suggestion is similar to Hendrik and Manuri
One can react appropriately N - alkyl/aryl hydrazines with acetylacetone ( like Methylhydrazine, phenylhydrazines etc.) to get N-alkyl/aryl-3,5-dimethylpyrazoles. Suggestion is similar to Hendrik and Manuri
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It is , may simply taken pyrazole moiety and methylation by methyl iodide in proper solvent use and reaction conditions.
It is , may simply taken pyrazole moiety and methylation by methyl iodide in proper solvent use and reaction conditions.
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You can react acetylacetone with hidrazine monohydrate in ethanol
You can react acetylacetone with hidrazine monohydrate in ethanol
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Guareschi reaction can be used for the preparation of this compound. In this reaction ethyl cyanoacetate with ketone and ammonia react or in another way react 2-cyanoacrylates with cyanoacetamide.
Guareschi reaction can be used for the preparation of this compound. In this reaction ethyl cyanoacetate with ketone and ammonia react or in another way react 2-cyanoacrylates with cyanoacetamide.
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