Home >
Community >
Difference in leaving group ability due to variation in nucleophiles
Upvote
26
Downvote
+ Nucleophilicity
+ Chemistry
Posted by
Md. Nure Alam
Difference in leaving group ability due to variation in nucleophiles
The data which you are using to explain a groups tendency to act as a good leaving group is via a nucleophilic substitution reaction. Nucleophilic sub reactions are affected by 3 things mainly: the nucleophilicity of the nucleophile, the strength of the bond being broken and how easy is it for the leaving group to leave.
This means if you use a better nucleophile the substitution reaction will happen faster. so in the case of your data, you are comparing leaving groups using "relative rates". So the nucleophilicity of the nucleophile will end up impacting the rate. So by looking at two different nucleophiles you are looking at each nucleophiles nucleophilicity and the leaving group.
The data which you are using to explain a groups tendency to act as a good leaving group is via a nucleophilic substitution reaction. Nucleophilic sub reactions are affected by 3 things mainly: the nucleophilicity of the nucleophile, the strength of the bond being broken and how easy is it for the leaving group to leave.
This means if you use a better nucleophile the substitution reaction will happen faster. so in the case of your data, you are comparing leaving groups using "relative rates". So the nucleophilicity of the nucleophile will end up impacting the rate. So by looking at two different nucleophiles you are looking at each nucleophiles nucleophilicity and the leaving group.
Ok, granted that the nucleophiles have different hardness and so, they will have different rates of reaction when ccompared with each other. But why should that affect the leaving group ability for the same set of reactions of one nucleophile? How does relative rate of leaving groups vary for a nucleophile in this case?More
The data which you are using to explain a groups tendency to act as a good leaving group is via a nucleophilic substitution reaction. Nucleophilic sub reactions are affected by 3 things mainly: the nucleophilicity of the nucleophile, the strength of the bond being broken and how easy is it for the leaving group to leave.
This means if you use a better nucleophile the substitution reaction will happen faster. so in the case of your data, you are comparing leaving groups using "relative rates". So the nucleophilicity of the nucleophile will end up impacting the rate. So by looking at two different nucleophiles you are looking at each nucleophiles nucleophilicity and the leaving group.
The data which you are using to explain a groups tendency to act as a good leaving group is via a nucleophilic substitution reaction. Nucleophilic sub reactions are affected by 3 things mainly: the nucleophilicity of the nucleophile, the strength of the bond being broken and how easy is it for the leaving group to leave.
This means if you use a better nucleophile the substitution reaction will happen faster. so in the case of your data, you are comparing leaving groups using "relative rates". So the nucleophilicity of the nucleophile will end up impacting the rate. So by looking at two different nucleophiles you are looking at each nucleophiles nucleophilicity and the leaving group.
More
VOTE
VOTE
VOTE