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Home > Community > Discussion as to Choosing Proper H1 or C13-NMR Solvents
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Pain Doctor Specialist at PHARMALIME .NET

Discussion as to Choosing Proper H1 or C13-NMR Solvents

Calatcryptomathicdotcom Yeah  Follow
Even if the solubility is decreased, there may still be enough in solution to get a spectrum.More
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Chee-Eng, Lim  Follow
Otherwise I second water. Maybe with a drop of tfa to fully proyonate the amine, should increase aq. solubilityMore
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Harvey Wachtel  Follow
Well, I have tried to get a spectra. However, the NMR machine seems to have trouble with the sample. There are way too many inconsistent peaks. I have tried to prepare a sample and then run it through a sonicator even, but to no avail. As for the case of water, I have mostly used ACN during the purification procedures, so I doubt that it would work. But there is no harm in trying :)More
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Donald Propp  Follow
how did you purify it? if it's very insoluble, you could make the amine salt which would make it soluble in D2O.More
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Fred McGalliard  Follow
I have purified it first via prep-TLC and then HPLC. The mobile phases were mostly ACN. Thanks for the suggestion.More
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Armando Viray  Follow
Maybe D2O? I am assuming you have a free amine now which should help water solubility quite a bitMore
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Anil Mukhiya  Follow
...D2O?More
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Aldino Piva  Follow
If it’s stable under acidic conditions try d-TFAMore
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