The landlord's experimental scheme has many problems, and the first cystine has three reaction sites: sulfhydryl, amino group, carboxy group, and two other activity are high, must be protected first; second, oil phase react need to take into account cysteineThe solubility involves many physical information findings; third, it is necessary to consider the chemical environment near unsaturated ketone to design the reaction temperature and the reaction.The reaction is generally alkaline conditions, and the bases such as K2CO3, KF can be catalyzed, and there is a small amount of Michael response to occur under acidic conditions, and the specific reaction is integrated
The landlord's experimental scheme has many problems, and the first cystine has three reaction sites: sulfhydryl, amino group, carboxy group, and two other activity are high, must be protected first; second, oil phase react need to take into account cysteineThe solubility involves many physical information findings; third, it is necessary to consider the chemical environment near unsaturated ketone to design the reaction temperature and the reaction.The reaction is generally alkaline conditions, and the bases such as K2CO3, KF can be catalyzed, and there is a small amount of Michael response to occur under acidic conditions, and the specific reaction is integrated
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