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How can reduce the boiling point of DMF or DMSO?
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Matthew Arslan
How can reduce the boiling point of DMF or DMSO?
Dear bhaskar, Solvents with higher boiling points such as water (100 °C at standard atmospheric pressure, 760 torr or 1 bar), dimethylformamide (DMF, 153 °C at the same), or dimethyl sulfoxide (DMSO, 189 °C at the same), can also be evaporated if the unit's vacuum system is capable of sufficiently low pressure. (For instance, both DMF and DMSO will boil below 50 °C if the vacuum is reduced from 760 torr to 5 torr [from 1 bar to 6.6 mbar]) However, more recent developments are often applied in these cases (e.g., evaporation while centrifuging or vortexing at high speeds). Rotary evaporation for high boiling hydrogen bond-forming solvents such as water is often a last recourse, as other evaporation methods or freeze-drying (lyophilization) are available. This is partly due to the fact that in such solvents, the tendency to "bump" is accentuated. The modern centrifugal evaporation technologies are particularly useful when one has many samples to do in parallel, as in medium- to high-throughput synthesis now expanding in industry and academia.regards, nagaraju.
Dear bhaskar, Solvents with higher boiling points such as water (100 °C at standard atmospheric pressure, 760 torr or 1 bar), dimethylformamide (DMF, 153 °C at the same), or dimethyl sulfoxide (DMSO, 189 °C at the same), can also be evaporated if the unit's vacuum system is capable of sufficiently low pressure. (For instance, both DMF and DMSO will boil below 50 °C if the vacuum is reduced from 760 torr to 5 torr [from 1 bar to 6.6 mbar]) However, more recent developments are often applied in these cases (e.g., evaporation while centrifuging or vortexing at high speeds). Rotary evaporation for high boiling hydrogen bond-forming solvents such as water is often a last recourse, as other evaporation methods or freeze-drying (lyophilization) are available. This is partly due to the fact that in such solvents, the tendency to "bump" is accentuated. The modern centrifugal evaporation technologies are particularly useful when one has many samples to do in parallel, as in medium- to high-throughput synthesis now expanding in industry and academia.regards, nagaraju.
I have the same question i am looking for how to get ride of Dimethyelacetamide in vacum oven under what temp. ? If you find the answer pls let me know Regards,
I have the same question i am looking for how to get ride of Dimethyelacetamide in vacum oven under what temp. ? If you find the answer pls let me know Regards,
Dear Aya... "The BP is 165 C and even under vacuum it can be challenging to evaporate. You will need a vacuum pressure less than 1mbar to evaporate this at room temperature. A rotary evaporator is typically too leaky to achieve this. Also, watch out for the the cold trap, you need a really good one as else DMA will condense in all kinds of places and then it will damage components of your system. If you have many samples then loo for a Genevac system as these are resistant to these kinds of agressive solvents" Quoted from Rob Darrington Or check https://www.researchgate.net/post/What_are_the_methods_for_drying_N_N-Dimethylacetamide_DMA
Dear Aya... "The BP is 165 C and even under vacuum it can be challenging to evaporate. You will need a vacuum pressure less than 1mbar to evaporate this at room temperature. A rotary evaporator is typically too leaky to achieve this. Also, watch out for the the cold trap, you need a really good one as else DMA will condense in all kinds of places and then it will damage components of your system. If you have many samples then loo for a Genevac system as these are resistant to these kinds of agressive solvents" Quoted from Rob Darrington Or check https://www.researchgate.net/post/What_are_the_methods_for_drying_N_N-Dimethylacetamide_DMA
Just simply reducing the pressure, you will find the boiling point have decreased for both solvents. A common example is material drying in vacuum oven , when the temperature is much below than 100o C still water gets removed completely from materials within a few minutes. You can try a demo in your vacuum oven for these solvents
Just simply reducing the pressure, you will find the boiling point have decreased for both solvents. A common example is material drying in vacuum oven , when the temperature is much below than 100o C still water gets removed completely from materials within a few minutes. You can try a demo in your vacuum oven for these solvents
Dear bhaskar,
Solvents with higher boiling points such as water (100 °C at standard atmospheric pressure, 760 torr or 1 bar), dimethylformamide (DMF, 153 °C at the same), or dimethyl sulfoxide (DMSO, 189 °C at the same), can also be evaporated if the unit's vacuum system is capable of sufficiently low pressure. (For instance, both DMF and DMSO will boil below 50 °C if the vacuum is reduced from 760 torr to 5 torr [from 1 bar to 6.6 mbar]) However, more recent developments are often applied in these cases (e.g., evaporation while centrifuging or vortexing at high speeds). Rotary evaporation for high boiling hydrogen bond-forming solvents such as water is often a last recourse, as other evaporation methods or freeze-drying (lyophilization) are available. This is partly due to the fact that in such solvents, the tendency to "bump" is accentuated. The modern centrifugal evaporation technologies are particularly useful when one has many samples to do in parallel, as in medium- to high-throughput synthesis now expanding in industry and academia.regards, nagaraju.
Dear bhaskar,
Solvents with higher boiling points such as water (100 °C at standard atmospheric pressure, 760 torr or 1 bar), dimethylformamide (DMF, 153 °C at the same), or dimethyl sulfoxide (DMSO, 189 °C at the same), can also be evaporated if the unit's vacuum system is capable of sufficiently low pressure. (For instance, both DMF and DMSO will boil below 50 °C if the vacuum is reduced from 760 torr to 5 torr [from 1 bar to 6.6 mbar]) However, more recent developments are often applied in these cases (e.g., evaporation while centrifuging or vortexing at high speeds). Rotary evaporation for high boiling hydrogen bond-forming solvents such as water is often a last recourse, as other evaporation methods or freeze-drying (lyophilization) are available. This is partly due to the fact that in such solvents, the tendency to "bump" is accentuated. The modern centrifugal evaporation technologies are particularly useful when one has many samples to do in parallel, as in medium- to high-throughput synthesis now expanding in industry and academia.regards, nagaraju.
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Dear nagaraju Pala...
Can you give me a valid reference to this?
Dear nagaraju Pala...
Can you give me a valid reference to this?
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I have the same question
i am looking for how to get ride of Dimethyelacetamide in vacum oven under what temp. ?
If you find the answer pls let me know
Regards,
I have the same question
i am looking for how to get ride of Dimethyelacetamide in vacum oven under what temp. ?
If you find the answer pls let me know
Regards,
More
VOTE
Thank you for your answer...Nagaraju Pala
Thank you for your answer...Nagaraju Pala
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Dear Aya...
"The BP is 165 C and even under vacuum it can be challenging to evaporate. You will need a vacuum pressure less than 1mbar to evaporate this at room temperature. A rotary evaporator is typically too leaky to achieve this. Also, watch out for the the cold trap, you need a really good one as else DMA will condense in all kinds of places and then it will damage components of your system. If you have many samples then loo for a Genevac system as these are resistant to these kinds of agressive solvents"
Quoted from Rob Darrington
Or check
https://www.researchgate.net/post/What_are_the_methods_for_drying_N_N-Dimethylacetamide_DMA
Dear Aya...
"The BP is 165 C and even under vacuum it can be challenging to evaporate. You will need a vacuum pressure less than 1mbar to evaporate this at room temperature. A rotary evaporator is typically too leaky to achieve this. Also, watch out for the the cold trap, you need a really good one as else DMA will condense in all kinds of places and then it will damage components of your system. If you have many samples then loo for a Genevac system as these are resistant to these kinds of agressive solvents"
Quoted from Rob Darrington
Or check
https://www.researchgate.net/post/What_are_the_methods_for_drying_N_N-Dimethylacetamide_DMA
More
VOTE
Just simply reducing the pressure, you will find the boiling point have decreased for both solvents. A common example is material drying in vacuum oven , when the temperature is much below than 100o C still water gets removed completely from materials within a few minutes. You can try a demo in your vacuum oven for these solvents
Just simply reducing the pressure, you will find the boiling point have decreased for both solvents. A common example is material drying in vacuum oven , when the temperature is much below than 100o C still water gets removed completely from materials within a few minutes. You can try a demo in your vacuum oven for these solvents
More
VOTE